PMID- 12599696
OWN - NLM
STAT- MEDLINE
DCOM- 20150505
LR  - 20030225
IS  - 1001-4454 (Print)
IS  - 1001-4454 (Linking)
VI  - 25
IP  - 8
DP  - 2002 Aug
TI  - [Preventive and therapeutic effects of extract from Rheum palmatum on hepatic 
      encephalopathy in rats with acute liver failure].
PG  - 573-5
AB  - OBJECTIVE: To probe the preventive, therapeutic effect and the possible mechanism 
      of extract from Rheum palmatum (ERP) on hepatic encephalopathy(HE) in rats with 
      acute liver failure. METHODS: HE was induced by the administration of 300 mg 
      thioracetamide per kg body weight by gavage on two consecutive days. The effects 
      of ERP were observed on neurology test, serum ammonium, serum endotoxin and liver 
      impairment. RESULTS: ERP could improve rat neuro-reflexes, decrease the staging 
      of HE and rat serum ammonium, endotoxin concentrations, and reduce the liver 
      impairment. CONCLUSION: ERP significantly prevents and treats HE in rats with 
      thioacetamide-induced acute liver failure.
FAU - Zhang, Qiuju
AU  - Zhang Q
AD  - Anhui College of Traditional Chinese Medicine, Hefei 230038.
FAU - Cheng, Huijuan
AU  - Cheng H
FAU - Wang, Chengyong
AU  - Wang C
FAU - Zhang, Changwei
AU  - Zhang C
FAU - Wang, Jun
AU  - Wang J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Yao Cai
JT  - Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
JID - 9426370
RN  - 0 (Ammonium Compounds)
RN  - 0 (Endotoxins)
RN  - 0 (Plant Extracts)
RN  - 075T165X8M (Thioacetamide)
SB  - IM
MH  - Ammonium Compounds/blood
MH  - Animals
MH  - Endotoxins/blood
MH  - Hepatic Encephalopathy/*drug therapy/etiology/*prevention & control
MH  - *Liver Failure, Acute/chemically induced/complications
MH  - Plant Extracts/*pharmacology
MH  - Rats
MH  - Rheum/*chemistry
MH  - Thioacetamide
EDAT- 2003/02/26 04:00
MHDA- 2015/05/06 06:00
CRDT- 2003/02/26 04:00
PHST- 2003/02/26 04:00 [pubmed]
PHST- 2015/05/06 06:00 [medline]
PHST- 2003/02/26 04:00 [entrez]
PST - ppublish
SO  - Zhong Yao Cai. 2002 Aug;25(8):573-5.