PMID- 12599781
OWN - NLM
STAT- MEDLINE
DCOM- 20031212
LR  - 20140625
VI  - 16
IP  - 6
DP  - 2002 Jun
TI  - [The expressions of telomerase activity and cyclinD1 protein in laryngeal 
      squamous cell carcinoma].
PG  - 286-8
AB  - OBJECTIVE: In order to investigate the telomerase activity and its relationship 
      with the overexpression of cyclin D1 protein in laryngeal squamous cell 
      carcinomas (LSCC). METHOD: TRAP(Telomeric repeat amplification protocol) assay 
      and immunohistochemical method were used respectively to detect the telomerase 
      activity and the overexpression of cyclin D1 protein in 38 LSCC and correspondent 
      laryngeal mucosa. RESULT: The expressions of telomerase and cyclin D1 protein 
      were 82%(31/38), 50%(19/38) respectively in LSCC, both of them were not 
      associated with the age of patients, location of tumors, T stage and pathological 
      grade(P > 0.05), but there was a significant difference among clnic stages (P < 
      0.05) in telomerase activity, no significant difference could be found among 
      clinic stages in expression of cyclin D1. 18 out of 31 cases were expressed in 
      both of them simultaneously there was significant association between them(P < 
      0.05). CONCLUSION: Telomerase is widely activated in LSCC, the overexpression of 
      cyclin D1 protein may be one of the most important mechanisms of telomerase 
      activation in LSCC.
FAU - Yu, Zilong
AU  - Yu Z
AD  - EENT Hospital, Shanghai Fudan University, Shanghai 200031.
FAU - Wang, Wei
AU  - Wang W
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 136601-57-5 (Cyclin D1)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Carcinoma, Squamous Cell/*enzymology/metabolism/pathology
MH  - Cyclin D1/*biosynthesis
MH  - Humans
MH  - Laryngeal Neoplasms/*enzymology/metabolism/pathology
MH  - Telomerase/*metabolism
EDAT- 2003/02/26 04:00
MHDA- 2003/12/13 05:00
CRDT- 2003/02/26 04:00
PHST- 2003/02/26 04:00 [pubmed]
PHST- 2003/12/13 05:00 [medline]
PHST- 2003/02/26 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 Jun;16(6):286-8.