PMID- 12600814
OWN - NLM
STAT- MEDLINE
DCOM- 20030903
LR  - 20061115
IS  - 1044-1549 (Print)
IS  - 1044-1549 (Linking)
VI  - 29
IP  - 2
DP  - 2003 Aug
TI  - Human leukocyte antigen-DR alleles influence the clinical course of pulmonary 
      sarcoidosis in Asian Indians.
PG  - 225-31
AB  - Host genetic factors are known to contribute to disease susceptibility and course 
      in sarcoidosis. They may also be important in defining the pattern of disease 
      presentation and progression, as well as its overall prognosis. We have studied 
      human leukocyte antigen (HLA) class I (n = 31) and class II alleles (n = 56) in a 
      cohort of Indian patients with sarcoidosis and 275 healthy control subjects from 
      north India. Although no specific HLA class I allele association was found among 
      sarcoidosis, the functional classification of HLA-A, -B, and -Cw alleles into 
      supertypes revealed an increased frequency of group 2 ligands (Cw2, Cw4, Cw5) for 
      the Killer cell Ig-like receptors (KIR2DL1) in the patient group as compared with 
      control subjects. Among class II alleles, positive association of DRB1*11, 
      DRB1*14, DQA1*0101/4, and DQB1*0503 alleles with the disease was noticed. 
      Clinical follow-up of the patient cohort up to a 5-yr period showed a predominant 
      occurrence of DRB1*14 and its linked DQ alleles in patients with insidious onset, 
      advanced disease on chest radiographs, and chronic course with frequent relapses 
      on tapering off the prednisolone treatment. Further, multivariate logistic 
      regression analysis revealed that the presence of DRB1*11(odds ratio [OR] 9) and 
      DRB1*14 (OR 7), and absence of DRB1*07 (OR 63 and DQB1*0201(OR 3) alleles, were 
      independent predictors of sarcoidosis. The present findings imply that 
      HLA-associated genetic factors influence the risk for the development of 
      sarcoidosis and disease progression.
FAU - Sharma, Surendra K
AU  - Sharma SK
AD  - Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 
      029, India. surensk@hotmail.com
FAU - Balamurugan, Arumugam
AU  - Balamurugan A
FAU - Pandey, Ravindra M
AU  - Pandey RM
FAU - Saha, Pradip Kumar
AU  - Saha PK
FAU - Mehra, Narinder K
AU  - Mehra NK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030214
PL  - United States
TA  - Am J Respir Cell Mol Biol
JT  - American journal of respiratory cell and molecular biology
JID - 8917225
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - HLA-DR Antigens/*genetics/*immunology
MH  - Haplotypes
MH  - Humans
MH  - Immunophenotyping
MH  - India
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Polymorphism, Genetic
MH  - Sarcoidosis, Pulmonary/ethnology/*immunology/pathology
MH  - Treatment Outcome
EDAT- 2003/02/26 04:00
MHDA- 2003/09/04 05:00
CRDT- 2003/02/26 04:00
PHST- 2003/02/26 04:00 [pubmed]
PHST- 2003/09/04 05:00 [medline]
PHST- 2003/02/26 04:00 [entrez]
AID - 2003-0007OC [pii]
AID - 10.1165/rcmb.2003-0007OC [doi]
PST - ppublish
SO  - Am J Respir Cell Mol Biol. 2003 Aug;29(2):225-31. doi: 10.1165/rcmb.2003-0007OC. 
      Epub 2003 Feb 14.