PMID- 12601107
OWN - NLM
STAT- MEDLINE
DCOM- 20040129
LR  - 20190514
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 60
IP  - 4
DP  - 2003 Feb 25
TI  - HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG 
      bands. Human leukocyte antigen.
PG  - 647-51
AB  - BACKGROUND: Oligoclonal IgG bands (OCB) are present in most patients with MS in 
      Western countries; however, in Japanese MS patients, the OCB-positive rate is not 
      as high. A relationship between immunogenetic backgrounds, namely, human 
      leukocyte antigen (HLA) DR2 and DR4 positivity, and OCB production in MS patients 
      from Hokkaido, the northernmost island of Japan, has been previously suggested by 
      the authors. OBJECTIVES: To investigate the role of OCB in Japanese MS and to 
      verify the interaction between immunogenetic backgrounds and OCB positivity. 
      METHODS: OCB, DR2(15), and DR4 positivity were studied in 45 patients with newly 
      diagnosed MS. In addition to confirming the authors' previous findings, the 
      clinical and demographic features, MRI findings, OCB positivity, and DRB1*15 and 
      DRB1*04 polymorphisms of an expanded data set of 99 MS patients were investigated 
      by using multivariate analysis. Patients with opticospinal MS (OS-MS) were 
      excluded from this study. RESULTS: A relatively low OCB-positive rate (53.3%), 
      HLA-DR15 association with OCB-positive MS (p = 0.0044), and DR4 association with 
      OCB-negative MS (p = 0.0410) were confirmed. DR15 was not associated with 
      OCB-negative MS. Demographic features, disease course, and disability were 
      similar in the OCB-negative and OCB-positive group, whereas there was a 
      preponderance of women in the OCB-positive group. An independent negative 
      association of DRB1*0405 (p = 0.0021, adjusted odds ratio = 0.21) with OCB 
      positivity was found. CONCLUSIONS: MS is heterogeneous in its association with 
      HLA alleles, and based on the immunogenetic differences, the MS patients in this 
      population include at least two HLA-related subpopulations with and without OCB.
FAU - Kikuchi, S
AU  - Kikuchi S
AD  - Department of Neurology, Hokkaido University Graduate School of Medicine, 
      Sapporo, Japan. skikuti@med.hokudai.ac.jp
FAU - Fukazawa, T
AU  - Fukazawa T
FAU - Niino, M
AU  - Niino M
FAU - Yabe, I
AU  - Yabe I
FAU - Miyagishi, R
AU  - Miyagishi R
FAU - Hamada, T
AU  - Hamada T
FAU - Hashimoto, S A
AU  - Hashimoto SA
FAU - Tashiro, K
AU  - Tashiro K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR15 antigen)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Oligoclonal Bands)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Disability Evaluation
MH  - Female
MH  - Gene Frequency
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR2 Antigen/genetics
MH  - HLA-DR4 Antigen/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Testing
MH  - Humans
MH  - Japan/epidemiology
MH  - Logistic Models
MH  - Magnetic Resonance Imaging/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/epidemiology/*genetics/*immunology
MH  - Odds Ratio
MH  - Oligoclonal Bands/blood/cerebrospinal fluid/*immunology
MH  - Polymorphism, Genetic
MH  - Sex Distribution
EDAT- 2003/02/26 04:00
MHDA- 2004/01/30 05:00
CRDT- 2003/02/26 04:00
PHST- 2003/02/26 04:00 [pubmed]
PHST- 2004/01/30 05:00 [medline]
PHST- 2003/02/26 04:00 [entrez]
AID - 10.1212/01.wnl.0000048202.09147.9e [doi]
PST - ppublish
SO  - Neurology. 2003 Feb 25;60(4):647-51. doi: 10.1212/01.wnl.0000048202.09147.9e.