PMID- 12603706
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20191106
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 14
IP  - 1
DP  - 2003 Feb
TI  - Study on the Prevention of Allergy in Children in Europe (SPACE): allergic 
      sensitization at 1 year of age in a controlled trial of allergen avoidance from 
      birth.
PG  - 10-7
AB  - Several studies have demonstrated that early intervention may modulate the 
      natural course of atopic disease. The objective of this study was to prevent 
      sensitization to house dust mite and food allergens, as well as development of 
      atopic symptoms, during infancy. To achieve this we employed the combination of 
      an educational package with the use of mite allergen-impermeable mattress 
      encasings. A multi-center European, population-based, randomized controlled study 
      of children at increased atopic risk [study on the prevention of Allergy in 
      Children in Europe (SPACE)] was performed in five countries (Austria, Germany, 
      Greece, Great Britain, Lithuania) and included three cohorts of schoolchildren, 
      toddlers and newborns. We report on the newborn cohort. A total of 696 newborns 
      were included in Austria, Great Britain and Germany. Inclusion criteria were a 
      positive history of parental allergy and a positive skin-prick test or specific 
      immunoglobulin E (IgE) of >or= 1.43 kU/l against at least one out of a panel of 
      common aeroallergens in one or both parents. At 1 year of age the overall 
      sensitization rate against the tested allergens [dust mite allergens: 
      Dermatophagoides pteronyssinus and D. farinae (Der p and Der f, respectively)] 
      and food allergens (egg, milk) in the prophylactic group was 6.21% vs. 10.67% in 
      the control group. The prevalence of sensitization against Der p was 1.86% in the 
      prophylactic group vs. 5% in the control group. In conclusion, we demonstrated, 
      in a group of newborns at risk for atopic diseases, that the sensitization rate 
      to a panel of aero- and food allergens could be effectively decreased through the 
      use of impermeable mattress encasings and the implementation of preventive 
      measures that were easy to perform.
FAU - Halmerbauer, Gerhard
AU  - Halmerbauer G
AD  - University Children's Hospital, Wahringer Gurtel, Vienna, Austria.
FAU - Gartner, Christian
AU  - Gartner C
FAU - Schierl, Michael
AU  - Schierl M
FAU - Arshad, Hassan
AU  - Arshad H
FAU - Dean, Tara
AU  - Dean T
FAU - Koller, Dieter Y
AU  - Koller DY
FAU - Karmaus, Wilfried
AU  - Karmaus W
FAU - Kuehr, Joachim
AU  - Kuehr J
FAU - Forster, Johannes
AU  - Forster J
FAU - Urbanek, Radvan
AU  - Urbanek R
FAU - Frischer, Thomas
AU  - Frischer T
CN  - SPACE Collaborative Study Team
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Antigens, Dermatophagoides)
SB  - IM
MH  - Allergens/immunology
MH  - Antigens, Dermatophagoides/immunology
MH  - Bedding and Linens
MH  - Cohort Studies
MH  - Egg Hypersensitivity/epidemiology/immunology/prevention & control
MH  - Europe/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/epidemiology/immunology/*prevention & control
MH  - Immunization
MH  - Incidence
MH  - Infant Welfare
MH  - Infant, Newborn
MH  - Male
MH  - Milk Hypersensitivity/epidemiology/immunology/prevention & control
MH  - Patient Compliance
MH  - Prospective Studies
MH  - Risk Factors
MH  - Risk Reduction Behavior
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2003/02/27 04:00
MHDA- 2003/07/26 05:00
CRDT- 2003/02/27 04:00
PHST- 2003/02/27 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2003/02/27 04:00 [entrez]
AID - 2o069 [pii]
AID - 10.1034/j.1399-3038.2003.02069.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2003 Feb;14(1):10-7. doi: 
      10.1034/j.1399-3038.2003.02069.x.