PMID- 12605041
OWN - NLM
STAT- MEDLINE
DCOM- 20030415
LR  - 20190916
IS  - 0277-3740 (Print)
IS  - 0277-3740 (Linking)
VI  - 22
IP  - 2
DP  - 2003 Mar
TI  - The influence of keratoplasty on visual prognosis in aniridia: a historical 
      review of one large family.
PG  - 105-10
AB  - PURPOSE: To evaluate the visual prognosis in aniridia and the influence of 
      keratoplasty in one large family. METHODS: The medical charts of 30 affected 
      members of this family were studied retrospectively. Their eyes were divided in 
      keratoplasty and nonkeratoplasty groups. In the keratoplasty group, 42 
      keratoplasties (26 lamellar and 16 penetrating) were performed (20 eyes), with a 
      median follow-up of 18.5 years. In the nonkeratoplasty group, 18 eyes with 
      sufficient follow-up were included. Best corrected visual acuity ever measured 
      (BCVA-ever), BCVA at the last visit (end-BCVA), and the difference between 
      BCVA-ever and end-BCVA (long-term Delta-BCVA) were compared in those two groups. 
      Best postoperative VA (post-BCVA), the difference between pre- and post-BCVA 
      (short-term Delta-BCVA), and its duration and outcomes of the grafts were 
      evaluated in the keratoplasty group. Possible side effects of other procedures 
      and incidents related to aniridia were compared. RESULTS: The median BCVA-ever 
      was 1/10 in both groups. The median end-BCVA was 2/300 in the keratoplasty group 
      and 1.5/300 in the nonkeratoplasty group; the long-term Delta-BCVA was comparable 
      in the two groups. There was a temporary improvement of BCVA in 36 of 42 eyes 
      after corneal transplantation, with a median of 8 logMAR and duration of 12 
      months. Most grafts failed because of recurrence of aniridic keratopathy. In the 
      keratoplasty group, there were more corneal infections and more retinal 
      detachments. The occurrence of glaucoma was comparable in both groups. In the 
      nonkeratoplasty group, more eyes (five versus three) lost light perception. 
      CONCLUSION: Corneal transplantation in aniridia provided only a temporary 
      improvement in VA in this family. The long-term visual outcome was not affected 
      by keratoplasty.
FAU - Tiller, Anna M
AU  - Tiller AM
AD  - Department of Ophthalmology, Academic Medical Center, 1100 DE Amsterdam, The 
      Netherlands.
FAU - Odenthal, Monica T P
AU  - Odenthal MT
FAU - Verbraak, Frank D
AU  - Verbraak FD
FAU - Gortzak-Moorstein, Nitza
AU  - Gortzak-Moorstein N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aniridia/*physiopathology
MH  - Corneal Dystrophies, Hereditary/physiopathology/*surgery
MH  - Female
MH  - Humans
MH  - Keratoplasty, Penetrating/*physiology
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Prognosis
MH  - Retrospective Studies
MH  - Visual Acuity/*physiology
EDAT- 2003/02/27 04:00
MHDA- 2003/04/16 05:00
CRDT- 2003/02/27 04:00
PHST- 2003/02/27 04:00 [pubmed]
PHST- 2003/04/16 05:00 [medline]
PHST- 2003/02/27 04:00 [entrez]
AID - 10.1097/00003226-200303000-00004 [doi]
PST - ppublish
SO  - Cornea. 2003 Mar;22(2):105-10. doi: 10.1097/00003226-200303000-00004.