PMID- 12605429
OWN - NLM
STAT- MEDLINE
DCOM- 20030626
LR  - 20181130
IS  - 0196-8092 (Print)
IS  - 0196-8092 (Linking)
VI  - 32
IP  - 3
DP  - 2003
TI  - Preliminary biocompatibility experiment of polymer films for laser-assisted 
      tissue welding.
PG  - 215-23
AB  - BACKGROUND AND OBJECTIVES: The purpose of this study was to examine the impact of 
      a polymer film for liquid solder strength reinforcement on the short term healing 
      of a wound closed by laser-tissue soldering. MATERIALS AND METHODS: Full 
      thickness incisions created on the dorsum of Sprague-Dawley rats were closed by 
      laser-tissue soldering: albumin solder with Indocyanine Green (ICG) dye was 
      inserted between the incision edges and photothermally coagulated with a diode 
      laser. A poly(DL-lactic-co-glycolic acid) (PLGA) polymer film was implanted 
      subcutaneously in the bottom of the incision (controls had no film). Specimens 
      were harvested at 0, 3, 7, and 14 days for breaking strength testing and 
      histological analysis. RESULTS: Breaking strengths of the controls at 0 and 14 
      days were statistically stronger than the specimens with the implanted films 
      (t-test, P < 0.05). A slight difficulty in apposing the wound edges due to the 
      film presence may have contributed to the low acute strengths. Interference with 
      the wound contraction process by the films possibly contributed to the lower 
      breaking strength at 14 days. Wound histology indicated a mild foreign body 
      reaction to the polymer film material. CONCLUSIONS: The polymer film was well 
      tolerated by the tissue, and the tissue response to the material was consistent 
      with that seen in the literature. The breaking strength differences between 
      control and film-implanted specimens at 0 and 14 days were probably the result of 
      mechanical complications (tissue apposition and wound contraction) due to the 
      presence of the film, and not due to the film material itself. The use of polymer 
      film patches for liquid solder reinforcement and breaking strength enhancement 
      may have certain application specific issues that need to be addressed. 
      Strategies to account for these issues require further research.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Sorg, Brian S
AU  - Sorg BS
AD  - Biomedical Engineering Program, University of Texas at Austin, 78712, USA. 
      brian.sorg@duke.edu
FAU - Welch, Ashley J
AU  - Welch AJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Lasers Surg Med
JT  - Lasers in surgery and medicine
JID - 8007168
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials
MH  - Disease Models, Animal
MH  - Female
MH  - Lactic Acid/*pharmacology
MH  - Laser Coagulation/*methods
MH  - Male
MH  - Polyglycolic Acid/*pharmacology
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*pharmacology
MH  - Probability
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reference Values
MH  - Sensitivity and Specificity
MH  - Skin/drug effects/pathology/*radiation effects
MH  - Tensile Strength
MH  - Wound Healing/physiology
MH  - Wounds and Injuries
EDAT- 2003/02/28 04:00
MHDA- 2003/06/27 05:00
CRDT- 2003/02/28 04:00
PHST- 2003/02/28 04:00 [pubmed]
PHST- 2003/06/27 05:00 [medline]
PHST- 2003/02/28 04:00 [entrez]
AID - 10.1002/lsm.10156 [doi]
PST - ppublish
SO  - Lasers Surg Med. 2003;32(3):215-23. doi: 10.1002/lsm.10156.