PMID- 12610052
OWN - NLM
STAT- MEDLINE
DCOM- 20030911
LR  - 20190516
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 26
IP  - 3
DP  - 2003 Mar
TI  - Soluble tumor necrosis factor-alpha receptors in young obese subjects with normal 
      and impaired glucose tolerance.
PG  - 875-80
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) is a possible link between 
      obesity and impaired glucose tolerance (IGT) and type 2 diabetes. Data about 
      TNF-alpha and soluble forms of its receptors (sTNFR1 and sTNFR2) in IGT are 
      controversial. The aim of the present study was to assess plasma TNF-alpha, 
      sTNFR1, and sTNFR2 levels and to evaluate the relationships with insulin 
      resistance in obese subjects with IGT. RESEARCH DESIGN AND METHODS: A total of 
      104 subjects participated in the present study: 30 obese subjects with IGT 
      (obese-IGT), 32 obese subjects with normal glucose tolerance (obese-NGT), and 42 
      lean healthy control subjects (control-NGT). Anthropometry and blood biochemical 
      parameters were measured and euglycemic-hyperinsulinemic clamp was performed. 
      RESULTS: Obese-IGT subjects were more insulin resistant in comparison with 
      obese-NGT and control-NGT groups; obese-NGT subjects were more insulin resistant 
      than control-NGT. Plasma sTNFR1 and sTNFR2 were markedly higher in both groups of 
      obese subjects in comparison with control-NGT and in the obese-IGT versus 
      obese-NGT group. Plasma sTNFR1 and sTNFR2 were inversely related to insulin 
      sensitivity. Both relationships remained significant after adjustment for age, 
      BMI, waist girth, percent body fat, plasma glucose, insulin, nonesterified fatty 
      acids, cholesterol, and triglycerides. Correlation between sTNFR2 and insulin 
      sensitivity was also present in all the groups analyzed separately, but the 
      correlation between sTNFR1 and insulin sensitivity was present only in the 
      obese-NGT group. CONCLUSIONS: Our data suggest that TNF-alpha receptors are 
      increased in obese-IGT subjects and are related to insulin resistance. These 
      findings indicate that the TNF-alpha system might contribute to the development 
      of insulin resistance in glucose-intolerant subjects.
FAU - Dzienis-Straczkowska, Stella
AU  - Dzienis-Straczkowska S
AD  - Department of Endocrinology, Academy, Bialystok, Poland. 
      stellastraczkowskal@poczta.onet.pl
FAU - Straczkowski, Marek
AU  - Straczkowski M
FAU - Szelachowska, Malgorzata
AU  - Szelachowska M
FAU - Stepien, Agnieszka
AU  - Stepien A
FAU - Kowalska, Irina
AU  - Kowalska I
FAU - Kinalska, Ida
AU  - Kinalska I
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Antigens, CD)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Antigens, CD/blood
MH  - Diabetes Mellitus/*blood/immunology
MH  - Etanercept
MH  - Female
MH  - Glucose Intolerance/*blood/immunology
MH  - Humans
MH  - Immunoglobulin G/*blood
MH  - Insulin Resistance/*immunology
MH  - Male
MH  - Middle Aged
MH  - *Obesity
MH  - Receptors, Tumor Necrosis Factor/*blood
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Sex Factors
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2003/03/01 04:00
MHDA- 2003/09/13 05:00
CRDT- 2003/03/01 04:00
PHST- 2003/03/01 04:00 [pubmed]
PHST- 2003/09/13 05:00 [medline]
PHST- 2003/03/01 04:00 [entrez]
AID - 10.2337/diacare.26.3.875 [doi]
PST - ppublish
SO  - Diabetes Care. 2003 Mar;26(3):875-80. doi: 10.2337/diacare.26.3.875.