PMID- 12610163
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20190508
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 77
IP  - 6
DP  - 2003 Mar
TI  - The type B leukemogenic virus truncated superantigen is dispensable for T-cell 
      lymphomagenesis.
PG  - 3866-70
AB  - Type B leukemogenic virus (TBLV) is a variant of mouse mammary tumor virus (MMTV) 
      that causes T-cell lymphomas in mice. We have constructed a TBLV-MMTV hybrid, 
      pHYB-TBLV, in which 756 bp of the C3H MMTV long terminal repeat (LTR) was 
      replaced with 438 bp of the TBLV LTR. Intraperitoneal injection of pHYB-TBLV 
      transfectants consistently resulted in T-cell lymphomas in 50% of injected 
      weanling BALB/c mice with an average latency period of 5.7 (+/- 1.5) months. 
      Transfectants of pHYB-TBLV containing a double-frameshift mutation in the 
      truncated superantigen gene (sag) induced T-cell lymphomas with similar 
      incidences, latency periods, and phenotypes, suggesting that cis-acting elements 
      in the TBLV LTR determine disease specificity.
FAU - Mustafa, Farah
AU  - Mustafa F
AD  - Section of Molecular Genetics and Microbiology and Institute for Cellular and 
      Molecular Biology, the University of Texas at Austin, Austin, Texas 78712, USA.
FAU - Bhadra, Sanchita
AU  - Bhadra S
FAU - Johnston, Dennis
AU  - Johnston D
FAU - Lozano, Mary
AU  - Lozano M
FAU - Dudley, Jaquelin P
AU  - Dudley JP
LA  - eng
GR  - P01 CA077760/CA/NCI NIH HHS/United States
GR  - R01 CA34780/CA/NCI NIH HHS/United States
GR  - R01 CA77760/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Superantigens)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Jurkat Cells
MH  - Lymphoma, T-Cell/*physiopathology/*virology
MH  - Male
MH  - Mammary Tumor Virus, Mouse/genetics/immunology/*pathogenicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Mutation
MH  - Recombination, Genetic
MH  - Retroviridae Infections/virology
MH  - Superantigens/*genetics/immunology
MH  - Terminal Repeat Sequences/genetics
MH  - Tumor Virus Infections/virology
PMC - PMC149533
EDAT- 2003/03/01 04:00
MHDA- 2003/04/04 05:00
PMCR- 2003/03/01
CRDT- 2003/03/01 04:00
PHST- 2003/03/01 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2003/03/01 04:00 [entrez]
PHST- 2003/03/01 00:00 [pmc-release]
AID - 2095 [pii]
AID - 10.1128/jvi.77.6.3866-3870.2003 [doi]
PST - ppublish
SO  - J Virol. 2003 Mar;77(6):3866-70. doi: 10.1128/jvi.77.6.3866-3870.2003.