PMID- 12611595
OWN - NLM
STAT- MEDLINE
DCOM- 20030616
LR  - 20191106
IS  - 1470-1626 (Print)
IS  - 1470-1626 (Linking)
VI  - 125
IP  - 3
DP  - 2003 Mar
TI  - The impact of endocrine disruptors on oocyte competence.
PG  - 313-25
AB  - To date, approximately 60 chemicals have been identified as endocrine disruptors: 
      exogenous agents that interfere with various aspects of natural hormone 
      physiology. The potential reproductive and health hazards of these environmental 
      chemicals have recently generated concern among the scientific community, policy 
      makers and general public. The present review presents and discusses the 
      available evidence that environmental chemicals are causing ovarian toxicity in 
      various species, with particular attention to farm animals. The impact of chronic 
      exposure to endocrine disruptors via food and drinking water cannot be neglected 
      when studying fertility problems in these species. This review focuses attention 
      on the superfamily of organochlorine chemicals, persistent organic pollutants 
      (POPs), because of their persistence in the environment, ability to concentrate 
      up the food chain, continued detection in environmental matrices and ability to 
      be stored in the adipose tissue of animals and humans. Published data clearly 
      indicate that POPs disrupt mammalian oocyte maturation and follicle physiology in 
      every species studied so far, including farm animals. However, as most of the 
      data available still derive from experiments performed on laboratory species or 
      in vitro models, great care should be taken when extrapolations to other species 
      or environmental situations are attempted.
FAU - Pocar, P
AU  - Pocar P
AD  - Department of Anatomy and Cell Biology, Martin Luther University, Halle (Saale) 
      Germany.
FAU - Brevini, T A L
AU  - Brevini TA
FAU - Fischer, B
AU  - Fischer B
FAU - Gandolfi, F
AU  - Gandolfi F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Reproduction
JT  - Reproduction (Cambridge, England)
JID - 100966036
RN  - 0 (Agrochemicals)
RN  - 0 (Dioxins)
RN  - 0 (Hormone Antagonists)
RN  - 0 (Insecticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Agrochemicals/*adverse effects
MH  - Animals
MH  - Animals, Domestic/*metabolism
MH  - Dioxins/adverse effects
MH  - Female
MH  - Hormone Antagonists/*adverse effects
MH  - Insecticides/adverse effects
MH  - Oogenesis/*drug effects
MH  - Ovarian Follicle/drug effects
MH  - Ovary/*drug effects
MH  - Polychlorinated Biphenyls/adverse effects
RF  - 112
EDAT- 2003/03/04 04:00
MHDA- 2003/06/17 05:00
CRDT- 2003/03/04 04:00
PHST- 2003/03/04 04:00 [pubmed]
PHST- 2003/06/17 05:00 [medline]
PHST- 2003/03/04 04:00 [entrez]
AID - 10.1530/rep.0.1250313 [doi]
PST - ppublish
SO  - Reproduction. 2003 Mar;125(3):313-25. doi: 10.1530/rep.0.1250313.