PMID- 12612281
OWN - NLM
STAT- MEDLINE
DCOM- 20030602
LR  - 20190605
IS  - 1098-4275 (Electronic)
IS  - 0031-4005 (Linking)
VI  - 111
IP  - 3
DP  - 2003 Mar
TI  - Allergen-specific immunoglobulin E antibodies in wheezing infants: the risk for 
      asthma in later childhood.
PG  - e255-61
AB  - OBJECTIVE: To evaluate whether the measurement of specific immunoglobulin E (IgE) 
      antibodies to food and/or inhalant allergens in infants who are hospitalized for 
      wheezing can be used to predict later asthma. METHODS: Eighty-two children who 
      were hospitalized for wheezing at <2 years of age were followed prospectively 
      until early school age. The baseline data and the characteristics of infancy had 
      been collected at enrollment. At school age, the children were evaluated for 
      asthma and allergic manifestations, including skin prick tests to common inhalant 
      allergens. Frozen serum samples obtained during the index episode of wheezing 
      were available for 80 children for determination of food and inhalant 
      allergen-specific serum IgE antibodies by fluoroenzyme-immunometric assay, 
      UniCAP, applying the Phadiatop Combi allergen panel. RESULTS: Asthma was present 
      in 32 (40%) children at school age. Food-specific IgE antibodies of >or=0.35 kU/L 
      were found in 37 (46%) wheezing infants, but only specific IgE to wheat and to 
      egg white at the level of >or=0.35 kU/L were significantly associated with later 
      asthma. In regard to specific IgE to the mixture of food allergens, the cutoff 
      level of >or=0.70 proved to be significant. Inhalant allergen-specific IgE of 
      >or=0.35 kU/L was found only in 14 cases (18%), but when present, it was 
      significantly predictive of asthma. Elevated levels of specific IgE antibodies to 
      food or inhalant allergens were significantly associated with allergic rhinitis 
      and skin-test reactivity at school age. CONCLUSIONS: When present in wheezing 
      infants, specific IgE of >or=0.35 kU/L to wheat, egg white, or inhalant allergens 
      are predictive of later childhood asthma. Consequently, detection of those 
      specific IgE antibodies in wheezing infants may facilitate the early diagnosis of 
      asthma, especially in cases with no clinically evident atopic manifestations.
FAU - Kotaniemi-Syrjanen, Anne
AU  - Kotaniemi-Syrjanen A
AD  - Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland. 
      kotaniem@hytti.uku.fi
FAU - Reijonen, Tiina M
AU  - Reijonen TM
FAU - Romppanen, Jarkko
AU  - Romppanen J
FAU - Korhonen, Kaj
AU  - Korhonen K
FAU - Savolainen, Kari
AU  - Savolainen K
FAU - Korppi, Matti
AU  - Korppi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pediatrics
JT  - Pediatrics
JID - 0376422
RN  - 0 (Allergens)
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Allergens/administration & dosage/*immunology
MH  - Asthma/diagnosis/*epidemiology/immunology
MH  - Blood Proteins/immunology
MH  - Bronchial Provocation Tests
MH  - Child, Institutionalized/statistics & numerical data
MH  - Child, Preschool
MH  - Eosinophil Granule Proteins
MH  - Female
MH  - Follow-Up Studies
MH  - Food/adverse effects
MH  - Food Hypersensitivity/immunology
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Infant
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radioallergosorbent Test
MH  - Respiratory Sounds/diagnosis/*immunology
MH  - *Ribonucleases
MH  - Risk Factors
MH  - Skin Tests
MH  - Surveys and Questionnaires
EDAT- 2003/03/04 04:00
MHDA- 2003/06/05 05:00
CRDT- 2003/03/04 04:00
PHST- 2003/03/04 04:00 [pubmed]
PHST- 2003/06/05 05:00 [medline]
PHST- 2003/03/04 04:00 [entrez]
AID - 10.1542/peds.111.3.e255 [doi]
PST - ppublish
SO  - Pediatrics. 2003 Mar;111(3):e255-61. doi: 10.1542/peds.111.3.e255.