PMID- 12615603
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20190513
IS  - 0002-9262 (Print)
IS  - 0002-9262 (Linking)
VI  - 157
IP  - 5
DP  - 2003 Mar 1
TI  - HLA-DPB1 and chronic beryllium disease: a HuGE review.
PG  - 388-98
AB  - The human leukocyte antigen (HLA) complex is a series of genes located on 
      chromosome 6 that are important in normal immune function. Susceptibility to 
      chronic beryllium disease, a granulomatous lung disease that appears in workers 
      exposed to beryllium, is modified by genetic variants of the HLA-DP subregion. 
      Evaluation of HLA-DPB1 sequence motifs in current and former beryllium workers 
      implicated a glutamic acid residue at position 69 (HLA-DPB1(Glu69)) in chronic 
      beryllium disease. This finding has since been extended to specific 
      HLA-DPB1(Glu69) alleles. Specific job tasks have also been implicated in degree 
      of risk, and in this paper the authors explore gene-environment interaction. The 
      utility of this genetic information for prospective, current, and former 
      beryllium workers must be weighed against the potential for employment and 
      insurance discrimination. Continued research in the beryllium-exposed population 
      will be important for improving personal risk assessment and identifying 
      high-risk genes associated with disease progression.
FAU - McCanlies, Erin C
AU  - McCanlies EC
AD  - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, 
      National Institute for Occupational Safety and Health, Centers for Disease 
      Control and Prevention, Morgantown, WV 26505, USA. eim4@cdc.gov
FAU - Kreiss, Kathleen
AU  - Kreiss K
FAU - Andrew, Michael
AU  - Andrew M
FAU - Weston, Ainsley
AU  - Weston A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Berylliosis/epidemiology/*genetics
MH  - Chromosomes, Human, Pair 6
MH  - Chronic Disease
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Genetic Variation
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP beta-Chains
MH  - Humans
MH  - Occupational Diseases/*genetics
RF  - 79
EDAT- 2003/03/05 04:00
MHDA- 2003/03/28 05:00
CRDT- 2003/03/05 04:00
PHST- 2003/03/05 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2003/03/05 04:00 [entrez]
AID - 10.1093/aje/kwg001 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2003 Mar 1;157(5):388-98. doi: 10.1093/aje/kwg001.