PMID- 12615891
OWN - NLM
STAT- MEDLINE
DCOM- 20030827
LR  - 20220409
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 21
DP  - 2003
TI  - Tolerogenic dendritic cells.
PG  - 685-711
AB  - Dendritic cells (DCs) have several functions in innate and adaptive immunity. In 
      addition, there is increasing evidence that DCs in situ induce antigen-specific 
      unresponsiveness or tolerance in central lymphoid organs and in the periphery. In 
      the thymus DCs generate tolerance by deleting self-reactive T cells. In 
      peripheral lymphoid organs DCs also induce tolerance to antigens captured by 
      receptors that mediate efficient uptake of proteins and dying cells. Uptake by 
      these receptors leads to the constitutive presentation of antigens on major 
      histocompatibility complex (MHC) class I and II products. In the steady state the 
      targeting of DC antigen capture receptors with low doses of antigens leads to 
      deletion of the corresponding T cells and unresponsiveness to antigenic 
      rechallenge with strong adjuvants. In contrast, if a stimulus for DC maturation 
      is coadministered with the antigen, the mice develop immunity, including 
      interferon-gamma-secreting effector T cells and memory T cells. There is also new 
      evidence that DCs can contribute to the expansion and differentiation of T cells 
      that regulate or suppress other immune T cells. One possibility is that distinct 
      developmental stages and subsets of DCs and T cells can account for the different 
      pathways to peripheral tolerance, such as deletion or suppression. We suggest 
      that several clinical situations, including autoimmunity and certain infectious 
      diseases, can be influenced by the antigen-specific tolerogenic role of DCs.
FAU - Steinman, Ralph M
AU  - Steinman RM
AD  - Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New 
      York, New York 10021-6399, USA. steinma@mail.rockefeller.edu
FAU - Hawiger, Daniel
AU  - Hawiger D
FAU - Nussenzweig, Michel C
AU  - Nussenzweig MC
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20011219
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (Antigens, CD)
RN  - 0 (DEC-205 receptor)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose Receptor)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, CD/metabolism
MH  - Clonal Deletion
MH  - Dendritic Cells/*immunology
MH  - Endocytosis
MH  - Humans
MH  - *Immune Tolerance
MH  - Islets of Langerhans/immunology
MH  - Lectins, C-Type/metabolism
MH  - Mannose Receptor
MH  - Mannose-Binding Lectins/metabolism
MH  - Minor Histocompatibility Antigens
MH  - Models, Immunological
MH  - Receptors, Cell Surface/metabolism
MH  - T-Lymphocytes/immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Thymus Gland/cytology/immunology
RF  - 165
EDAT- 2003/03/05 04:00
MHDA- 2003/08/28 05:00
CRDT- 2003/03/05 04:00
PHST- 2003/03/05 04:00 [pubmed]
PHST- 2003/08/28 05:00 [medline]
PHST- 2003/03/05 04:00 [entrez]
AID - 120601.141040 [pii]
AID - 10.1146/annurev.immunol.21.120601.141040 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2003;21:685-711. doi: 10.1146/annurev.immunol.21.120601.141040. 
      Epub 2001 Dec 19.