PMID- 12616603
OWN - NLM
STAT- MEDLINE
DCOM- 20030916
LR  - 20080723
IS  - 0270-3211 (Print)
IS  - 0270-3211 (Linking)
VI  - Suppl 1
DP  - 2003
TI  - Developmental toxicity evaluation of the new fluoroquinolone antibacterial DW-116 
      in rats.
PG  - 123-36
AB  - We have recently reported that the fluoroquinolone antibacterial DW-116 induces a 
      significant developmental toxicity in rat. The present study was conducted to 
      better understand the teratogenic effects of DW-116 at several developmental 
      toxic doses in rats. DW-116 was orally administered to pregnant rats from 
      gestational day (GD) 6 through 16 at dose levels of 0, 320, 400, and 500 
      mg/kg/day. All dams were subjected to caesarean section on GD 20 and their 
      fetuses were examined for external, visceral, and skeletal abnormalities. At 
      above 400 mg/kg, severe decreases in maternal body weight gain, food consumption, 
      litter size, fetal weight and placental weight, and severe increases in 
      resorption rate and fetal morphological alterations were observed. At 320 mg/kg, 
      mild decreases in maternal body weight gain, food consumption, fetal weight and 
      placental weight, and mild increases in fetal variations and retardations were 
      observed. These results suggest that DW-116 is embryotoxic at above 320 mg/kg/day 
      and is embryolethal and teratogenic at above 400 mg/kg in pregnant rats and that 
      DW-116 is a selective developmental toxicant in rat conceptuses.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Kim, Jong-Choon
AU  - Kim JC
AD  - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of 
      Korea. toxkim@chonnam.ac.kr
FAU - Shin, Dong-Ho
AU  - Shin DH
FAU - Kim, Sung-Ho
AU  - Kim SH
FAU - Ahn, Tae-Ho
AU  - Ahn TH
FAU - Kang, Seong-Soo
AU  - Kang SS
FAU - Jang, Beom-Su
AU  - Jang BS
FAU - Kim, Choong-Yong
AU  - Kim CY
FAU - Chung, Moon-Koo
AU  - Chung MK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Teratog Carcinog Mutagen
JT  - Teratogenesis, carcinogenesis, and mutagenesis
JID - 8100917
RN  - 0 (Anti-Infective Agents)
RN  - 0 (DW-116)
RN  - 0 (Fluoroquinolones)
RN  - 0 (Piperazines)
RN  - 0 (Quinolones)
SB  - IM
MH  - Abnormalities, Drug-Induced/genetics
MH  - Administration, Oral
MH  - Animals
MH  - Anti-Infective Agents/administration & dosage/chemistry/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Embryonic and Fetal Development/*drug effects/genetics
MH  - Female
MH  - Fetal Weight/drug effects/genetics
MH  - Fetus/chemistry/drug effects/metabolism
MH  - *Fluoroquinolones
MH  - Gestational Age
MH  - Maternal-Fetal Exchange/drug effects/genetics
MH  - Molecular Structure
MH  - Organ Size/drug effects/genetics
MH  - Piperazines/administration & dosage/chemistry/*toxicity
MH  - Placenta/drug effects
MH  - Pregnancy
MH  - Quinolones/administration & dosage/chemistry/*toxicity
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2003/03/05 04:00
MHDA- 2003/09/17 05:00
CRDT- 2003/03/05 04:00
PHST- 2003/03/05 04:00 [pubmed]
PHST- 2003/09/17 05:00 [medline]
PHST- 2003/03/05 04:00 [entrez]
AID - 10.1002/tcm.10066 [doi]
PST - ppublish
SO  - Teratog Carcinog Mutagen. 2003;Suppl 1:123-36. doi: 10.1002/tcm.10066.