PMID- 12617866
OWN - NLM
STAT- MEDLINE
DCOM- 20031120
LR  - 20191106
IS  - 1521-6926 (Print)
IS  - 1521-6926 (Linking)
VI  - 15
IP  - 4
DP  - 2002 Dec
TI  - Acute lymphoblastic leukaemia: diagnosis and classification.
PG  - 597-621
AB  - Acute lymphoblastic leukaemia (ALL) is a heterogeneous disease with distinct 
      biological and prognostic groupings. Diagnosis relies on traditional 
      cytomorphological and immunohistochemical evaluation of the leukaemic blasts. 
      Subsequently, cytogenetic analysis identifies clonal numeric and/or structural 
      chromosomal abnormalities that may be present, thus confirming the subtype 
      classification and providing important prognostic information for treatment 
      planning. The major chromosomal abnormalities in ALL are t(9;22)(q34;q11), 
      t(12;21)(p13;q22), t(4;11)(q21;q23), t(1;19)(q23;p13), 8q24 translocations and 
      hyperdiploidy. Generally, hyperdiploidy, occurring most frequently in paediatric 
      cases, is associated with a good prognosis, while hypodiploidy confers a poor 
      prognosis. Among structural chromosomal abnormalities, the t(9;22)(q34;q11) 
      resulting in the BCR/ABL fusion protein, and rearrangements of the MLL gene, 
      confer a poor prognosis in both children and adults, while t(12;21)(p13;q22), 
      resulting in the TEL/AML1 fusion protein, and del (12p) confer a good prognosis. 
      More recently, additional diagnostic and prognostic information has been gained 
      from fluorescence in situ hybridization (FISH) and DNA microarray techniques.
FAU - Kebriaei, Partow
AU  - Kebriaei P
AD  - Section of Hematology/Oncology, Department of Medicine and Cancer Research 
      Center, University of Chicago, Chicago, Illinois 60637, USA.
FAU - Anastasi, John
AU  - Anastasi J
FAU - Larson, Richard A
AU  - Larson RA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Haematol
JT  - Best practice & research. Clinical haematology
JID - 101120659
SB  - IM
MH  - Cell Lineage/genetics
MH  - Chromosome Aberrations
MH  - Cytological Techniques/methods
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Immunophenotyping
MH  - Oligonucleotide Array Sequence Analysis
MH  - Precursor Cell Lymphoblastic 
      Leukemia-Lymphoma/*classification/*diagnosis/genetics/pathology
MH  - Prognosis
RF  - 107
EDAT- 2003/03/06 04:00
MHDA- 2003/12/03 05:00
CRDT- 2003/03/06 04:00
PHST- 2003/03/06 04:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/03/06 04:00 [entrez]
AID - S1521692602902240 [pii]
AID - 10.1053/beha.2002.0224 [doi]
PST - ppublish
SO  - Best Pract Res Clin Haematol. 2002 Dec;15(4):597-621. doi: 
      10.1053/beha.2002.0224.