PMID- 12618207
OWN - NLM
STAT- MEDLINE
DCOM- 20030616
LR  - 20191106
IS  - 1368-8375 (Print)
IS  - 1368-8375 (Linking)
VI  - 39
IP  - 3
DP  - 2003 Apr
TI  - Infiltrating intramuscular lipoma of the temporal muscle. A case report with 
      molecular cytogenetic analysis.
PG  - 316-22
AB  - Intramuscular lipomas are uncommon benign mesenchymal tumors which infiltrate 
      skeletal muscle and are exceedingly rare in the head and neck region. Because of 
      the infiltrating nature of the lesion and a high propensity for recurrence, they 
      are sometimes difficult to distinguish from well-differentiated liposarcomas 
      (WDLS). We report, the first case of an infiltrating lipoma of the temporal 
      muscle in a 62-year-old white man who presented with a slow growing mass in the 
      left temporal region. The histopathological examination showed diffuse 
      infiltration of the striated muscle fibers by mature adipocytes. There were no 
      lipoblasts or cells with atypical nuclei as described in WDLS. We performed 
      interphase fluorescence in situ hybridization (FISH) analyses using painting 
      probes for chromosome 12 and a specific probe for the MDM2 gene and comparative 
      genomic hybridization. The results did not identify MDM2 or 12q amplification and 
      therefore confirmed the benign nature of the lesion.
FAU - Scolozzi, P
AU  - Scolozzi P
AD  - Division of Reconstructive Surgery, Maxillofacial Surgery Unit, Geneva University 
      Hospital, Switzerland.
FAU - Lombardi, T
AU  - Lombardi T
FAU - Maire, G
AU  - Maire G
FAU - Pedeutour, F
AU  - Pedeutour F
FAU - Richter, M
AU  - Richter M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Chromosomes, Human, Pair 12/genetics
MH  - Humans
MH  - Lipoma/diagnosis/*genetics
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Muscle Neoplasms/diagnosis/*genetics
MH  - Neoplasm Proteins/genetics
MH  - *Nuclear Proteins
MH  - Proto-Oncogene Proteins/genetics
MH  - Proto-Oncogene Proteins c-mdm2
MH  - *Temporal Muscle
EDAT- 2003/03/06 04:00
MHDA- 2003/06/17 05:00
CRDT- 2003/03/06 04:00
PHST- 2003/03/06 04:00 [pubmed]
PHST- 2003/06/17 05:00 [medline]
PHST- 2003/03/06 04:00 [entrez]
AID - S1368837502001173 [pii]
AID - 10.1016/s1368-8375(02)00117-3 [doi]
PST - ppublish
SO  - Oral Oncol. 2003 Apr;39(3):316-22. doi: 10.1016/s1368-8375(02)00117-3.