PMID- 12618575
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20161019
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 35
IP  - 3
DP  - 2003 Mar
TI  - Independent and combined effects of amino acids and glucose after resistance 
      exercise.
PG  - 449-55
AB  - PURPOSE: This study was designed to assess the independent and combined effects 
      of a dose of amino acids (approximately 6 g) and/or carbohydrate (approximately 
      35 g) consumed at 1 and 2 h after resistance exercise on muscle protein 
      metabolism. METHODS: Following initiation of a primed constant infusion of H 
      -phenylalanine and N-urea, volunteers performed leg resistance exercise and then 
      ingested one of three drinks (amino acids (AA), carbohydrate (CHO), or AA and CHO 
      (MIX)) at 1- and 2-h postexercise.(5) RESULTS: Total net uptake of phenylalanine 
      across the leg over 3 h was greatest in response to MIX and least in CHO. The 
      individual values for CHO, MIX, and AA were 53 +/- 6, 114 +/- 38, and 71 +/- 13 
      mg x leg x 3h. Stimulation of net uptake in MIX was due to increased muscle 
      protein synthesis. CONCLUSIONS: These findings indicate that the combined effect 
      on net muscle protein synthesis of carbohydrate and amino acids given together 
      after resistance exercise is roughly equivalent to the sum of the independent 
      effects of either given alone. The individual effects of carbohydrate and amino 
      acids are likely dependent on the amount of each that is ingested. Further, prior 
      intake of amino acids and carbohydrate does not diminish the metabolic response 
      to a second comparable dose ingested 1h later.
FAU - Miller, Sharon L
AU  - Miller SL
AD  - Dairy Management, Inc, Rosemont, IL, USA.
FAU - Tipton, Kevin D
AU  - Tipton KD
FAU - Chinkes, David L
AU  - Chinkes DL
FAU - Wolf, Steven E
AU  - Wolf SE
FAU - Wolfe, Robert R
AU  - Wolfe RR
LA  - eng
GR  - P30 AG024832/AG/NIA NIH HHS/United States
GR  - DK 38010/DK/NIDDK NIH HHS/United States
GR  - M01 RR00073/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Amino Acids)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Drug Combinations)
RN  - 0 (Insulin)
RN  - 0 (Muscle Proteins)
RN  - 8W8T17847W (Urea)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Amino Acids/*administration & dosage
MH  - Area Under Curve
MH  - Biomarkers/blood
MH  - Blood Circulation/physiology
MH  - Blood Glucose/drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Drug Combinations
MH  - Exercise/*physiology
MH  - Female
MH  - Glucose/*administration & dosage
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Muscle Proteins/*drug effects
MH  - Reference Values
MH  - Time
MH  - Urea/metabolism
OTO - NASA
OT  - Non-programmatic
EDAT- 2003/03/06 04:00
MHDA- 2003/07/18 05:00
CRDT- 2003/03/06 04:00
PHST- 2003/03/06 04:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2003/03/06 04:00 [entrez]
AID - 10.1249/01.MSS.0000053910.63105.45 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2003 Mar;35(3):449-55. doi: 
      10.1249/01.MSS.0000053910.63105.45.