PMID- 12619167
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20071115
IS  - 1045-2257 (Print)
IS  - 1045-2257 (Linking)
VI  - 36
IP  - 4
DP  - 2003 Apr
TI  - Human homeobox gene HOXC13 is the partner of NUP98 in adult acute myeloid 
      leukemia with t(11;12)(p15;q13).
PG  - 420-3
AB  - The chimeric gene NUP98/HOXC13 was detected in a patient with a de novo acute 
      myeloid leukemia and a t(11;12)(p15;q13). Fluorescence in situ hybridization with 
      PAC1173K1 identified the breakpoint on 11p15, indicating that the NUP98 gene was 
      involved in the translocation. At 12q13, the breakpoint fell within BAC 578A18, 
      selected for the homeobox C (HOXC) cluster genes. RACE-PCR showed that HOXC13 was 
      the partner gene of NUP98. To date, HOXC13 is the eighth homeobox gene that, as 
      the result of a reciprocal translocation, fuses with NUP98 in myeloid 
      malignancies.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - La Starza, Roberta
AU  - La Starza R
AD  - Hematology and Bone Marrow Transplantation Unit, University of Perugia, 
      Policlinico Monteluce, via Brunamonti, 06123 Perugia, Italy.
FAU - Trubia, Maurizio
AU  - Trubia M
FAU - Crescenzi, Barbara
AU  - Crescenzi B
FAU - Matteucci, Caterina
AU  - Matteucci C
FAU - Negrini, Massimo
AU  - Negrini M
FAU - Martelli, Massimo F
AU  - Martelli MF
FAU - Pelicci, Pier Giuseppe
AU  - Pelicci PG
FAU - Mecucci, Cristina
AU  - Mecucci C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genes Chromosomes Cancer
JT  - Genes, chromosomes & cancer
JID - 9007329
RN  - 0 (NUP98-HOXC13 fusion protein, human)
RN  - 0 (Oncogene Proteins, Fusion)
SB  - IM
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid, Acute/diagnosis/drug therapy/*genetics
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/genetics
MH  - Neoplasms, Second Primary/genetics
MH  - Oncogene Proteins, Fusion/*genetics
EDAT- 2003/03/06 04:00
MHDA- 2003/04/04 05:00
CRDT- 2003/03/06 04:00
PHST- 2003/03/06 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2003/03/06 04:00 [entrez]
AID - 10.1002/gcc.10182 [doi]
PST - ppublish
SO  - Genes Chromosomes Cancer. 2003 Apr;36(4):420-3. doi: 10.1002/gcc.10182.