PMID- 12619772
OWN - NLM
STAT- MEDLINE
DCOM- 20030616
LR  - 20191106
IS  - 1464-0325 (Print)
IS  - 1464-0325 (Linking)
VI  - 5
IP  - 1
DP  - 2003 Feb
TI  - Change in levels of persistent organic pollutants in human plasma after 
      consumption of a traditional northern Norwegian fish dish-molje (cod, cod liver, 
      cod liver oil and hard roe).
PG  - 160-5
AB  - The traditional northern Norwegian fish dish "molje", consisting of boiled cod, 
      cod liver, cod liver oil and hard roe, is still consumed frequently during the 
      winter months January to March. The liver of the cod is rich in lipids and the 
      levels of persistent organic pollutants (POPs) are relatively high. To better 
      understand the short-term consequences of this traditional meal on the plasma 
      levels of PCBs and p,p'-DDE, individual intake of liver and cod liver oil during 
      one meal was measured. Blood samples were collected from 33 participants before 
      the meal, and then 4 h, 12 h and 5 days after it. Lipid-weight and wet-weight 
      levels of 10 PCB congeners and p,p'-DDE were determined in the plasma samples and 
      the food. The plasma levels of p,p'-DDE was found to increase significantly from 
      0 to 4 h, both when expressed as wet-weight (35% change) and lipid-weight (20% 
      change). The corresponding changes (0-4 h) in wet-weight levels of the most 
      prevalent PCB congeners were non significant. By contrast, PCB congeners with low 
      levels in the food showed a significant drop in lipid-weight levels during the 
      first 4 h. The observed changes were independent of amount consumed. Significant 
      differences in fasting and non-fasting samples were found for most PCBs and 
      p,p'-DDE. For the lipid weight levels of sum PCBs there was a significant 
      decrease of 16% from non-fasting to fasting samples. To obtain reliable data on 
      human levels of POPs it is, on the basis of these findings, recommended that 
      blood samples should be collected from fasting individuals and both wet-weight 
      and lipid-weight levels should be reported.
FAU - Sandanger, Torkjel M
AU  - Sandanger TM
AD  - Norwegian Institute for Air Research, The Polar Environmental Centre, No-9296 
      Tromso, Norway. torkjel.sandanger@nilu.no
FAU - Brustad, Magritt
AU  - Brustad M
FAU - Lund, Eiliv
AU  - Lund E
FAU - Burkow, Ivan C
AU  - Burkow IC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Environ Monit
JT  - Journal of environmental monitoring : JEM
JID - 100968688
RN  - 0 (Environmental Pollutants)
RN  - 0 (Insecticides)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 8001-69-2 (Cod Liver Oil)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Cod Liver Oil/*chemistry
MH  - Dichlorodiphenyl Dichloroethylene/analysis/*blood
MH  - Environmental Pollutants/analysis/*blood
MH  - Female
MH  - *Fishes
MH  - *Food Contamination
MH  - Humans
MH  - Insecticides/analysis/*blood
MH  - Liver/chemistry
MH  - Male
MH  - Middle Aged
MH  - Norway
MH  - Polychlorinated Biphenyls/analysis/*blood
MH  - Public Health
MH  - Reproducibility of Results
EDAT- 2003/03/07 04:00
MHDA- 2003/06/17 05:00
CRDT- 2003/03/07 04:00
PHST- 2003/03/07 04:00 [pubmed]
PHST- 2003/06/17 05:00 [medline]
PHST- 2003/03/07 04:00 [entrez]
AID - 10.1039/b210517a [doi]
PST - ppublish
SO  - J Environ Monit. 2003 Feb;5(1):160-5. doi: 10.1039/b210517a.