PMID- 12619969
OWN - NLM
STAT- MEDLINE
DCOM- 20030911
LR  - 20161124
IS  - 0145-5680 (Print)
IS  - 0145-5680 (Linking)
VI  - 48
IP  - 7
DP  - 2002 Nov
TI  - The effect of murine B16F10 melanoma on the biodistribution of 99mTc-MDP in male 
      C57BL/6J mice.
PG  - 747-50
AB  - The biodistribution of radiopharmaceuticals used in diagnostic imaging can be 
      altered by a wide variety of factors. We studied the effect of murine B16F10 
      melanoma on the biodistribution in mice of 99mTechnetium-methylenediphosphonic 
      acid (99mTc-MDP). Viable B16-F10 cell lines (1 x 10(5)) were inoculated 
      subcutaneously in the dorsal region of 8-12 week-old male isogenic C57BV/6j mice. 
      14-16 days after inoculation, 99mTc-MDP was injected in the ocular plexus and 
      after 0.5 hr the animals were rapidly sacrificed. The organs and tumor were 
      isolated, the mass determined and the percentage per gram of injected activity 
      (%ATI/g) calculated. The results shown that the %ATI/g:i/ has not been altered in 
      inguinal lymph nodes, prostate, pancreas, testis, seminal vesicle, bladder, 
      kidney, stomach, small intestine, spleen, thymus, heart, lung, brain and muscle; 
      but ii/ significantly decreased in thyroid, bone, blood and liver. In conclusion, 
      the B16F10 melanoma can alter the 99mTc-MDP uptakes in some organs.
FAU - Aguiar, Ronaldo O
AU  - Aguiar RO
AD  - Instituto Nacional do Cancer, Servico de Pesquisa Basica, Praca Cruz Vermelha, 
      23, Rio de Janeiro, Brazil.
FAU - Kwee, Joly K
AU  - Kwee JK
FAU - de Paula, Emilio F
AU  - de Paula EF
FAU - Gomes, Maria Luisa
AU  - Gomes ML
FAU - Bernardo-Filho, Mario
AU  - Bernardo-Filho M
LA  - eng
PT  - Journal Article
PL  - France
TA  - Cell Mol Biol (Noisy-le-grand)
JT  - Cellular and molecular biology (Noisy-le-Grand, France)
JID - 9216789
RN  - 0 (Radiopharmaceuticals)
RN  - X89XV46R07 (Technetium Tc 99m Medronate)
SB  - IM
MH  - Animals
MH  - Male
MH  - Melanoma, Experimental/*diagnostic imaging/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals/*pharmacokinetics
MH  - Technetium Tc 99m Medronate/*pharmacokinetics
MH  - Tissue Distribution
EDAT- 2003/03/07 04:00
MHDA- 2003/09/13 05:00
CRDT- 2003/03/07 04:00
PHST- 2003/03/07 04:00 [pubmed]
PHST- 2003/09/13 05:00 [medline]
PHST- 2003/03/07 04:00 [entrez]
PST - ppublish
SO  - Cell Mol Biol (Noisy-le-grand). 2002 Nov;48(7):747-50.