PMID- 12620286
OWN - NLM
STAT- MEDLINE
DCOM- 20030613
LR  - 20190901
IS  - 0197-0186 (Print)
IS  - 0197-0186 (Linking)
VI  - 43
IP  - 2
DP  - 2003 Jul
TI  - Flupentixol and trifluperidol reduce secretion of tumor necrosis factor-alpha and 
      nitric oxide by rat microglial cells.
PG  - 173-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), both of which are 
      produced by activated microglial cells, are involved in the neuropathogenesis of 
      many diseases affecting the central nervous system (CNS). There is a need to 
      develop drugs that inhibit neurotoxic processes in neurodegenerative diseases. 
      The aim of this study was to evaluate the effect of two neuroleptics, flupentixol 
      and trifluperidol, on the release of pro-apoptotic TNF-alpha and NO by 
      LPS-activated rat microglial cells. Flupentixol and trifluperidol reduced the 
      TNF-alpha and NO release by cultured microglia exposed to LPS for 6 and 24h. The 
      results suggest that flupentixol and trifluperidol, which are well-known 
      antipsychotic drugs, may be used in the treatment of CNS diseases associated with 
      excessive TNF-alpha and NO release.
FAU - Kowalski, Jan
AU  - Kowalski J
AD  - Department of Clinical Pharmacology, Medical University of Silesia, 40-752 
      Katowice, 18, Medykow, Poland. farmklin@infomed.slam.katowice.pl
FAU - Labuzek, Krzysztof
AU  - Labuzek K
FAU - Herman, Zbigniew S
AU  - Herman ZS
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - FA0UYH6QUO (Flupenthixol)
RN  - R8869Q7R8I (Trifluperidol)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/drug effects/physiology
MH  - Cells, Cultured
MH  - Flupenthixol/*pharmacology
MH  - Neurons/drug effects/*metabolism
MH  - Nitric Oxide/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Trifluperidol/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2003/03/07 04:00
MHDA- 2003/06/14 05:00
CRDT- 2003/03/07 04:00
PHST- 2003/03/07 04:00 [pubmed]
PHST- 2003/06/14 05:00 [medline]
PHST- 2003/03/07 04:00 [entrez]
AID - S0197018602001638 [pii]
AID - 10.1016/s0197-0186(02)00163-8 [doi]
PST - ppublish
SO  - Neurochem Int. 2003 Jul;43(2):173-8. doi: 10.1016/s0197-0186(02)00163-8.