PMID- 12622883
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 2058-7384 (Electronic)
IS  - 0394-6320 (Linking)
VI  - 14
IP  - 1
DP  - 2001 Jan-Apr
TI  - Effect of TNF-alpha on the induction of apoptosis in murine macrophages: role of 
      interleukin-1 beta converting enzyme.
PG  - 5-10
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine that induces apoptosis in 
      various cell types via its binding to TNF-receptors (TNF-R). Involvement of 
      ICE-like protease in the induction of TNF-alpha mediated apoptosis in murine 
      macrophage was investigated using ICE inhibitor YVAD-cmk 
      (Tetrapeptide-Acetyl-Try-Val Ala-Asp-Chloromethyl ketone). Macrophages treated 
      with TNF showed a time dependent decrease in cell viability with a simultaneous 
      increase in the percent of cells showing apoptotic morphology and an increase in 
      percent DNA fragmentation, a quantitative measure of apoptosis. However, 
      incubation of macrophage in medium containing TNF and YVAD-cmk had inhibitory 
      effect on the TNF-induced apoptosis of macrophage. This finding suggests that 
      ICE-like protease may be involved in the induction of apoptosis in macrophage by 
      TNF-alpha.
FAU - Acharya, A
AU  - Acharya A
AD  - School of Biotechnology, Banaras Hindu University, Varanasi, India.
FAU - Singh, S M
AU  - Singh SM
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
EDAT- 2003/03/08 04:00
MHDA- 2003/03/08 04:00
CRDT- 2003/03/08 04:00
PHST- 2003/03/08 04:00 [pubmed]
PHST- 2003/03/08 04:00 [medline]
PHST- 2003/03/08 04:00 [entrez]
AID - 2 [pii]
AID - 10.1177/039463200101400102 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2001 Jan-Apr;14(1):5-10. doi: 
      10.1177/039463200101400102.