PMID- 12622886
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 2058-7384 (Electronic)
IS  - 0394-6320 (Linking)
VI  - 14
IP  - 1
DP  - 2001 Jan-Apr
TI  - Angiotensin II: a regulator of inflammation during renal disease?
PG  - 25-30
AB  - It has been recently recognized that besides its vasoactive actions Angiotensin 
      II (Ang II) exerts various immunomodulatory effects that may contribute to renal 
      injury and to the progression of renal disease. Consistent with this concept, Ang 
      II facilitates macrophage recruitment into the kidney either directly or through 
      the-upregulation of different chemotactic molecules such as RANTES (Regulated on 
      Activation Normal T Expressed and Secreted), monocyte chemoattractant protein-1 
      (MCP-1) and osteopontin. Infiltrating macrophages not only produce a number of 
      cytokines, growth factors and proinflammatory Mediators, but also synthesize Ang 
      II intacellularly which increases tissue levels of the hormone within the kidney. 
      Finally, specific binding sites for Ang II have been demonstrated on macrophages 
      and increasing evidence indicates that Ang II directly modulates many of the 
      cellular functions of these cells during the course of renal disease. Together 
      these data suggest that Ang II plays an important role in modulating inflammatory 
      responses in the kidney.
FAU - Antus, B
AU  - Antus B
AD  - Dept. Nephrology, University Hospital Essen, Germany.
FAU - Exton, M S
AU  - Exton MS
FAU - Rosivall, L
AU  - Rosivall L
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
EDAT- 2003/03/08 04:00
MHDA- 2003/03/08 04:00
CRDT- 2003/03/08 04:00
PHST- 2003/03/08 04:00 [pubmed]
PHST- 2003/03/08 04:00 [medline]
PHST- 2003/03/08 04:00 [entrez]
AID - 5 [pii]
AID - 10.1177/039463200101400105 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2001 Jan-Apr;14(1):25-30. doi: 
      10.1177/039463200101400105.