PMID- 12623297
OWN - NLM
STAT- MEDLINE
DCOM- 20030917
LR  - 20190901
IS  - 0022-2828 (Print)
IS  - 0022-2828 (Linking)
VI  - 35
IP  - 1
DP  - 2003 Jan
TI  - Structural determinants and biophysical properties of HERG and KCNQ1 channel 
      gating.
PG  - 27-35
AB  - The delayed rectifier K(+) currents, I(Kr) and I(Ks,) play a critical role in 
      modulating the plateau phase of the cardiac action potential. HERG encodes the 
      alpha-subunit of channels underlying I(Kr), while I(Ks) is composed of subunits 
      encoded by KCNQ1 and KCNE1. Mutations in any of these genes cause the long QT 
      syndrome, a disorder of myocellular repolarization that predisposes affected 
      individuals to life-threatening arrhythmias. Elucidation of the molecular basis 
      of these currents has led to significant advancements in our understanding of 
      fundamental properties of channel function. This review summarizes the current 
      state of knowledge regarding the structural determinants and biophysical 
      properties of HERG and KCNQ1 channels.
FAU - Tristani-Firouzi, Martin
AU  - Tristani-Firouzi M
AD  - Department of Pediatrics, Pediatric Cardiology, Suite 1500 PCMC, University of 
      Utah School of Medicine, 100 N. Medical Drive, Salt Lake City, UT 84113, USA. 
      mfirouzi@hmbg.utah.edu
FAU - Sanguinetti, Michael C
AU  - Sanguinetti MC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Mol Cell Cardiol
JT  - Journal of molecular and cellular cardiology
JID - 0262322
RN  - 0 (Cation Transport Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (ERG protein, human)
RN  - 0 (ERG1 Potassium Channel)
RN  - 0 (Ether-A-Go-Go Potassium Channels)
RN  - 0 (KCNH2 protein, human)
RN  - 0 (KCNH6 protein, human)
RN  - 0 (KCNQ Potassium Channels)
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
RN  - 0 (Potassium Channels)
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcriptional Regulator ERG)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - *Cation Transport Proteins
MH  - *DNA-Binding Proteins
MH  - ERG1 Potassium Channel
MH  - Ether-A-Go-Go Potassium Channels
MH  - Humans
MH  - KCNQ Potassium Channels
MH  - KCNQ1 Potassium Channel
MH  - Myocardium/metabolism
MH  - Potassium/metabolism
MH  - Potassium Channels/*chemistry/metabolism
MH  - *Potassium Channels, Voltage-Gated
MH  - *Trans-Activators
MH  - Transcriptional Regulator ERG
RF  - 84
EDAT- 2003/03/08 04:00
MHDA- 2003/09/18 05:00
CRDT- 2003/03/08 04:00
PHST- 2003/03/08 04:00 [pubmed]
PHST- 2003/09/18 05:00 [medline]
PHST- 2003/03/08 04:00 [entrez]
AID - S0022282802002869 [pii]
AID - 10.1016/s0022-2828(02)00286-9 [doi]
PST - ppublish
SO  - J Mol Cell Cardiol. 2003 Jan;35(1):27-35. doi: 10.1016/s0022-2828(02)00286-9.