PMID- 1262445
OWN - NLM
STAT- MEDLINE
DCOM- 19760706
LR  - 20131121
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 42
IP  - 4
DP  - 1976 Apr
TI  - Induction of hypertriglyceridemia by a low-fat diet.
PG  - 729-35
AB  - We have studied the effects of moderate dietary fat restriction on plasma 
      triglyceride, cholesterol, glucose, and insulin response in 27 subjects. Compared 
      with a control diet (45% fat, 40% carbohydrate [CHO], 15% protein) the low fat 
      (higher CHO) diet (30% fat, 55% CHO, 15% protein) produced a 41% increase in 
      fasting triglyceride level (155 +/- 17 to 219 +/- 23 mg%) with no change in 
      fasting plasma cholesterol level. Furthermore, this increase in triglyceride 
      levels; induced by the higher CHO content of the low fat diet, was seen in 26 out 
      of 27 subjects. Postprandial triglyceride, glucose, and insulin levels were also 
      higher on the low fat (higher CHO) diet. Since hypertriglyceridemia is a 
      significant risk factor for the development of coronary heart disease, and since 
      our data indicate that the moderate increase in dietary CHO associated with a low 
      fat diet will elevate plasma triglyceride levels, we believe that more caution is 
      necessary before recommending the wide-spread use of low fat diets for heart 
      disease prevention.
FAU - Ginsberg, H
AU  - Ginsberg H
FAU - Olefsky, J M
AU  - Olefsky JM
FAU - Kimmerling, G
AU  - Kimmerling G
FAU - Crapo, P
AU  - Crapo P
FAU - Reaven, G M
AU  - Reaven GM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cholesterol/blood
MH  - *Dietary Fats
MH  - Fasting
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/*blood/chemically induced
MH  - Insulin/blood
MH  - Male
MH  - Middle Aged
MH  - Triglycerides/*blood
EDAT- 1976/04/01 00:00
MHDA- 1976/04/01 00:01
CRDT- 1976/04/01 00:00
PHST- 1976/04/01 00:00 [pubmed]
PHST- 1976/04/01 00:01 [medline]
PHST- 1976/04/01 00:00 [entrez]
AID - 10.1210/jcem-42-4-729 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 1976 Apr;42(4):729-35. doi: 10.1210/jcem-42-4-729.