PMID- 12625389
OWN - NLM
STAT- MEDLINE
DCOM- 20030523
LR  - 20191025
IS  - 0284-4311 (Print)
IS  - 0284-4311 (Linking)
VI  - 37
IP  - 1
DP  - 2003
TI  - Effects of neurotrophic factors on chemokinesis of Schwann cells in culture.
PG  - 14-7
AB  - Schwann cells are support cells in the peripheral nervous system and are 
      responsible for migration, adhesion, production of the extracellular matrix, and 
      myelination. Migration is considered to be essential for nerve regeneration after 
      transsection. We have examined the chemokinetic effects of nerve growth factor 
      (NGF), brain derived growth factor (BDNF), and neurotrophin-3 (NT-3) on Schwann 
      cells in vitro using a chemotaxis chamber. The chemokinetic activity of Schwann 
      cells was strongly accelerated by NGF, but was not influenced by BDNF. NT-3 at a 
      concentration of 1 ng/ml had a stimulatory effect on chemokinesis. These data 
      suggest that NGF is a chemoattractant for Schwann cells in vitro. Giving 
      exogenous NGF might stimulate both migration of Schwann cells and the formation 
      of Bungner's bands after peripheral nerve injuries in animal models.
FAU - Maniwa, Sokichi
AU  - Maniwa S
AD  - Department of Orthopaedics, Shimane Medical University, Izumo, Shimane, Japan. 
      smaniwa@shimane-med.ac.jp
FAU - Iwata, Atsushi
AU  - Iwata A
FAU - Hirata, Hitoshi
AU  - Hirata H
FAU - Ochi, Mitsuo
AU  - Ochi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Plast Reconstr Surg Hand Surg
JT  - Scandinavian journal of plastic and reconstructive surgery and hand surgery
JID - 8707869
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cells, Cultured
MH  - Chemotactic Factors/*pharmacology
MH  - Male
MH  - Nerve Growth Factor/*pharmacology
MH  - Neurotrophin 3/*pharmacology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Sciatic Nerve/*injuries
EDAT- 2003/03/11 04:00
MHDA- 2003/05/24 05:00
CRDT- 2003/03/11 04:00
PHST- 2003/03/11 04:00 [pubmed]
PHST- 2003/05/24 05:00 [medline]
PHST- 2003/03/11 04:00 [entrez]
AID - 10.1080/alp.37.1.14.17 [doi]
PST - ppublish
SO  - Scand J Plast Reconstr Surg Hand Surg. 2003;37(1):14-7. doi: 
      10.1080/alp.37.1.14.17.