PMID- 12626616
OWN - NLM
STAT- MEDLINE
DCOM- 20030509
LR  - 20071114
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 89
IP  - 3
DP  - 2003 Mar
TI  - Synaptic modulation of the interspike interval signatures of bursting pyloric 
      neurons.
PG  - 1363-77
AB  - The pyloric network of the lobster stomatogastric nervous system is one of the 
      best described assemblies of oscillatory neurons producing bursts of action 
      potentials. While the temporal patterns of bursts have been investigated in 
      detail, those of spikes have received less attention. Here we analyze the 
      intraburst firing patterns of pyloric neurons and the synaptic interactions 
      shaping their dynamics in millisecond time scales not performed before. We find 
      that different pyloric neurons express characteristic, cell-specific firing 
      patterns in their bursts. Nonlinear analysis of the interspike intervals (ISIs) 
      reveals distinctive temporal structures ('interspike interval signatures'), which 
      are found to depend on the synaptic connectivity of the network. We compare ISI 
      patterns of the pyloric dilator (PD), lateral pyloric (LP), and ventricular 
      dilator (VD) neurons in 1) normal conditions, 2) after blocking glutamatergic 
      synaptic connections, and 3) in various functional configurations of the three 
      neurons. Manipulation of the synaptic connectivity results in characteristic 
      changes in the ISI signatures of the postsynaptic neurons. The intraburst firing 
      pattern of the PD neuron is regularized by the inhibitory synaptic connection 
      from the LP neuron as revealed in current-clamp experiments and also as 
      reconstructed with a dynamic clamp. On the other hand, mutual inhibition between 
      the LP and VD neurons tend to produce more irregular bursts with increased spike 
      jitter. The results show that synaptic interactions fine-tune the output of 
      pyloric neurons. The present data also suggest a way of processing of synaptic 
      information: bursting neurons are capable of encoding incoming signals by 
      altering the fine structure of their intraburst spike patterns.
FAU - Szucs, Attila
AU  - Szucs A
AD  - Institute for Nonlinear Science and Department of Physics and Marine Research 
      Laboratory, Scripps Institution of Oceanography, University of California San 
      Diego, La Jolla, California 92093-0402, USA. aszucs@ucsd.edu
FAU - Pinto, Reynaldo D
AU  - Pinto RD
FAU - Rabinovich, Michail I
AU  - Rabinovich MI
FAU - Abarbanel, Henry D I
AU  - Abarbanel HD
FAU - Selverston, Allen I
AU  - Selverston AI
LA  - eng
GR  - 1R01 NS-40110/NS/NINDS NIH HHS/United States
GR  - R01 NS-40110-01A2/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Electrophysiology
MH  - Ganglia, Invertebrate/cytology/physiology
MH  - Neural Inhibition/physiology
MH  - Neural Pathways
MH  - Neurons/*physiology
MH  - Palinuridae/*physiology
MH  - Pylorus/innervation
MH  - Synapses/*physiology
EDAT- 2003/03/11 04:00
MHDA- 2003/05/13 05:00
CRDT- 2003/03/11 04:00
PHST- 2003/03/11 04:00 [pubmed]
PHST- 2003/05/13 05:00 [medline]
PHST- 2003/03/11 04:00 [entrez]
AID - 89/3/1363 [pii]
AID - 10.1152/jn.00732.2002 [doi]
PST - ppublish
SO  - J Neurophysiol. 2003 Mar;89(3):1363-77. doi: 10.1152/jn.00732.2002.