PMID- 12626851
OWN - NLM
STAT- MEDLINE
DCOM- 20030707
LR  - 20181130
IS  - 1420-8008 (Print)
IS  - 1420-8008 (Linking)
VI  - 15
IP  - 4
DP  - 2003
TI  - An observational clinical study of the efficacy and tolerability of donepezil in 
      the treatment of Alzheimer's disease.
PG  - 189-98
AB  - An open-label, observational Post-Marketing Surveillance (PMS) study was 
      undertaken in Germany to examine the efficacy and tolerability of donepezil in 
      routine clinical practice. Alzheimer's disease (AD) patients were treated with 
      donepezil (5 or 10 mg once daily) and observed for a period of approximately 3 
      months. Study assessments included the Mini-Mental State Examination (MMSE), the 
      Nurses' Observation Scale for Geriatric Patients (NOSGER), and adverse events 
      (AEs). A total of 2,092 patients (mean age 73.0 years; mean +/- SD MMSE score 
      17.8 +/- 5.8) were included in the efficacy assessments. MMSE and NOSGER scores 
      showed statistically significant improvements in the total patient population and 
      in the subpopulations with severe AD or AD with concomitant Parkinsonian symptoms 
      (ADPS cohort). AEs were reported in a total of 12% of patients and were mostly 
      due to peripheral cholinergic effects. In this observational PMS study, donepezil 
      was shown to be an effective and well-tolerated therapy in the overall patient 
      population, in patients with severe AD, and in the ADPS cohort.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Hager, Klaus
AU  - Hager K
AD  - Department of Geriatrics, Henrietten Hospital, Hannover, Germany. 
      Geriatrie.Hannover@t-online.de
FAU - Calabrese, Pasquale
AU  - Calabrese P
FAU - Frolich, Lutz
AU  - Frolich L
FAU - Gobel, Claus
AU  - Gobel C
FAU - Berger, Frank M
AU  - Berger FM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Switzerland
TA  - Dement Geriatr Cogn Disord
JT  - Dementia and geriatric cognitive disorders
JID - 9705200
RN  - 0 (Cholinesterase Inhibitors)
RN  - 0 (Indans)
RN  - 0 (Piperidines)
RN  - 8SSC91326P (Donepezil)
SB  - IM
MH  - Activities of Daily Living
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/complications/*drug therapy
MH  - Cholinesterase Inhibitors/adverse effects/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Cohort Studies
MH  - Donepezil
MH  - Female
MH  - Humans
MH  - Indans/adverse effects/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Parkinsonian Disorders/complications
MH  - Piperidines/adverse effects/*therapeutic use
MH  - *Product Surveillance, Postmarketing
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Severity of Illness Index
MH  - Treatment Outcome
EDAT- 2003/03/11 04:00
MHDA- 2003/07/08 05:00
CRDT- 2003/03/11 04:00
PHST- 2002/09/28 00:00 [accepted]
PHST- 2003/03/11 04:00 [pubmed]
PHST- 2003/07/08 05:00 [medline]
PHST- 2003/03/11 04:00 [entrez]
AID - 68786 [pii]
AID - 10.1159/000068786 [doi]
PST - ppublish
SO  - Dement Geriatr Cogn Disord. 2003;15(4):189-98. doi: 10.1159/000068786.