PMID- 12626894
OWN - NLM
STAT- MEDLINE
DCOM- 20030416
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 32
IP  - 3
DP  - 2003 Mar 1
TI  - Human T-cell lymphotropic virus type I (HTLV-I)-related clinical and laboratory 
      findings for HTLV-I-infected blood donors.
PG  - 328-34
AB  - Clinical and laboratory findings were examined for 111 human T-cell lymphotropic 
      virus type I (HTLV-I)-infected blood donors. HTLV-I provirus loads in subjects 
      with a family history of adult T-cell leukemia (ATL) or HTLV-I-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP) tended to be higher than those 
      in subjects without a family history of these conditions. There were 3 
      asymptomatic patients with ATL, 4 with a history of uveitis, 7 with hyperreflexia 
      in the lower limbs, and 3 with urinary frequency in the night. The mean CD4 
      cell/CD8 cell ratio +/- SD was significantly lower (p<.0001) in subjects with 
      hyperreflexia in the lower limbs (1.3 +/- 0.2) than in subjects without any 
      clinical abnormalities (1.7 +/- 0.6), suggesting that subjects with hyperreflexia 
      in the lower limbs already have some immunologic abnormalities. The concordance 
      of HTLV-I infection between husband and wife was lower in this study than in a 
      previous study. HTLV-I-related inflammatory symptoms were more frequent (p =.021, 
      Fisher exact test; OR = 9.5; 95% CI, 1.7-53.5) in HTLV-I tax A-infected donors (3 
      [50%] of 6 donors) than in HTLV-I tax B-infected donors (10 [9.5%] of 105 
      donors), suggesting different risks of HTLV-I-related symptoms according to the 
      virus genotype.
FAU - Furukawa, Yoshitaka
AU  - Furukawa Y
AD  - Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 
      Japan. furukawy@m2.kufm.kagoshima-u.ac.jp
FAU - Kubota, Ryuji
AU  - Kubota R
FAU - Eiraku, Nobutaka
AU  - Eiraku N
FAU - Nakagawa, Masanori
AU  - Nakagawa M
FAU - Usuku, Koichiro
AU  - Usuku K
FAU - Izumo, Shuji
AU  - Izumo S
FAU - Osame, Mitsuhiro
AU  - Osame M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Adult
MH  - *Blood Donors
MH  - CD4-CD8 Ratio
MH  - Disease Transmission, Infectious
MH  - Family Health
MH  - Genes, pX
MH  - HTLV-I Infections/*diagnosis/epidemiology/transmission
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - Japan/epidemiology
MH  - Leg
MH  - Male
MH  - Middle Aged
MH  - Paraparesis, Tropical Spastic/diagnosis/etiology
MH  - Proviruses/genetics/*isolation & purification
MH  - Reflex, Abnormal/immunology
MH  - Sexually Transmitted Diseases, Viral/diagnosis
MH  - Spouses
MH  - Urination Disorders/diagnosis
MH  - Uveitis/diagnosis
MH  - Viral Load
EDAT- 2003/03/11 04:00
MHDA- 2003/04/17 05:00
CRDT- 2003/03/11 04:00
PHST- 2003/03/11 04:00 [pubmed]
PHST- 2003/04/17 05:00 [medline]
PHST- 2003/03/11 04:00 [entrez]
AID - 10.1097/00126334-200303010-00013 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2003 Mar 1;32(3):328-34. doi: 
      10.1097/00126334-200303010-00013.