PMID- 12629087
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20041117
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 88
IP  - 3
DP  - 2003 Mar
TI  - Prospective study of thymic carcinoids in patients with multiple endocrine 
      neoplasia type 1.
PG  - 1066-81
AB  - Little is known of the natural history of thymic carcinoids in multiple endocrine 
      neoplasia type 1 (MEN1). This is important because in 1993 they were identified 
      as a frequent cause of death, yet only small retrospective studies and case 
      reports exist. We report results of a prospective study of 85 patients with MEN1 
      evaluated for pancreatic endocrine tumors and followed over a mean of 8 yr with 
      serial chest computed tomography, magnetic resonance imaging (MRI), chest x-ray, 
      and, since 1994, octreoscans [somatostatin receptor scintigraphy (SRS)]. Seven 
      patients (8%) developed thymic carcinoids. Patients with and without carcinoids 
      did not differ in clinical, laboratory, or MEN1 tumor features, except for male 
      gender and the presence of a gastric carcinoid. All thymic tumors were hormonally 
      inactive. Four thymic carcinoids lacked 11q loss of heterozygosity, although it 
      was found in three pancreatic endocrine tumors. Computed tomography and/or MRI 
      were more sensitive than SRS or chest x-ray in detecting tumors initially or with 
      recurrence. All patients underwent resection of the thymic carcinoid, and in all 
      patients followed more than 1 yr, the tumor recurred. Bone metastases developed 
      in two patients and were detected early only on MRI, not SRS. This study provides 
      information on early thymic carcinoids and allows modifications of existing 
      guidelines to be recommended for their diagnosis, surveillance, and treatment.
FAU - Gibril, Fathia
AU  - Gibril F
AD  - Digestive Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, National Institutes of Health (NIH), Bethesda, Maryland 20892, 
      USA.
FAU - Chen, Yuan-Jia
AU  - Chen YJ
FAU - Schrump, David S
AU  - Schrump DS
FAU - Vortmeyer, Alexander
AU  - Vortmeyer A
FAU - Zhuang, Zhengping
AU  - Zhuang Z
FAU - Lubensky, Irina A
AU  - Lubensky IA
FAU - Reynolds, James C
AU  - Reynolds JC
FAU - Louie, Adeline
AU  - Louie A
FAU - Entsuah, Laurence K
AU  - Entsuah LK
FAU - Huang, Kane
AU  - Huang K
FAU - Asgharian, Behnam
AU  - Asgharian B
FAU - Jensen, Robert T
AU  - Jensen RT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Receptors, Somatostatin)
SB  - IM
MH  - Adult
MH  - Carcinoid Tumor/diagnosis/*etiology/genetics
MH  - Chromosomes, Human, Pair 11
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications
MH  - Prospective Studies
MH  - Radiography, Thoracic
MH  - Receptors, Somatostatin/analysis
MH  - Thymus Neoplasms/diagnosis/*etiology/genetics
MH  - Tomography, X-Ray Computed
MH  - Zollinger-Ellison Syndrome/etiology
EDAT- 2003/03/12 04:00
MHDA- 2003/03/28 05:00
CRDT- 2003/03/12 04:00
PHST- 2003/03/12 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2003/03/12 04:00 [entrez]
AID - 10.1210/jc.2002-021314 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2003 Mar;88(3):1066-81. doi: 10.1210/jc.2002-021314.