PMID- 12629649
OWN - NLM
STAT- MEDLINE
DCOM- 20030530
LR  - 20131121
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 70
IP  - 1
DP  - 2003 May
TI  - Elevated levels of total and dengue virus-specific immunoglobulin E in patients 
      with varying disease severity.
PG  - 91-8
AB  - The kinetics of total and dengue virus-specific immunoglobulin E (IgE) were 
      studied in serial serum samples obtained from 168 patients, 41 of whom suffered 
      from primary dengue virus infection and 127 suffered from secondary dengue virus 
      infection. Seventy-one patients were classified as dengue fever, 30 as dengue 
      hemorrhagic fever, and 67 as dengue shock syndrome. A control group included 
      single serum samples from patients with a herpes virus infection (n = 14), 
      non-dengue febrile patients (n = 10), and healthy blood donors (n = 10). Patients 
      with dengue virus infection had higher levels of total and dengue virus-specific 
      IgE than non-dengue patients (P < 0.05). Patients with secondary dengue virus 
      infections had not significantly increased levels of both total and dengue 
      virus-specific IgE in the acute phase of disease compared to patients with 
      primary dengue virus infections. Dengue virus-specific IgE was significantly 
      higher in dengue hemorrhagic fever and/or dengue shock syndrome patients compared 
      to dengue fever and non-dengue patients (P < 0.05). In conclusion, this study 
      showed elevated total and dengue virus-specific IgE serum antibody levels in the 
      acute stage of disease. Therefore, measurement of both total and dengue 
      virus-specific IgE serum antibodies can be used as an additional prognostic 
      marker in the development of severe complications in dengue virus infections. In 
      addition, the presence and increase of dengue virus-specific IgE serum antibodies 
      in patients with dengue virus infections is suggestive of the pathogenetic role 
      that IgE may play in the hemostatic disorders observed in dengue hemorrhagic 
      fever and dengue shock syndrome.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Koraka, Penelopie
AU  - Koraka P
AD  - Laboratory for Exotic Viral Infections, Institute of Virology, Erasmus Medical 
      Centre Rotterdam, The Netherlands.
FAU - Murgue, Bernadette
AU  - Murgue B
FAU - Deparis, Xavier
AU  - Deparis X
FAU - Setiati, Tatty E
AU  - Setiati TE
FAU - Suharti, Catarina
AU  - Suharti C
FAU - van Gorp, Eric C M
AU  - van Gorp EC
FAU - Hack, C E
AU  - Hack CE
FAU - Osterhaus, Albert D M E
AU  - Osterhaus AD
FAU - Groen, Jan
AU  - Groen J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antibodies, Viral)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Antibodies, Viral/*blood
MH  - Antibody Formation
MH  - Antibody Specificity
MH  - Child
MH  - Child, Preschool
MH  - Dengue Virus/*immunology
MH  - Female
MH  - Humans
MH  - Immunoassay
MH  - Immunoglobulin E/*blood/immunology
MH  - Infant
MH  - Kinetics
MH  - Male
MH  - Severe Dengue/blood/epidemiology/*immunology
MH  - Severity of Illness Index
EDAT- 2003/03/12 04:00
MHDA- 2003/05/31 05:00
CRDT- 2003/03/12 04:00
PHST- 2003/03/12 04:00 [pubmed]
PHST- 2003/05/31 05:00 [medline]
PHST- 2003/03/12 04:00 [entrez]
AID - 10.1002/jmv.10358 [doi]
PST - ppublish
SO  - J Med Virol. 2003 May;70(1):91-8. doi: 10.1002/jmv.10358.