PMID- 12631616
OWN - NLM
STAT- MEDLINE
DCOM- 20031003
LR  - 20221207
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 9
IP  - 3
DP  - 2003 Mar
TI  - Mouse mammary tumor virus-like gene sequences in breast tumors of Australian and 
      Vietnamese women.
PG  - 1118-20
AB  - PURPOSE: There is considerable evidence that the presence of mouse mammary tumor 
      virus (MMTV)-like gene sequences in human breast cancer is highly associated with 
      human breast carcinoma. Previous studies have found MMTV-like gene sequences in 
      38% of breast cancer tissue from United States women. The prevalence of these 
      sequences in Australian and Vietnamese women has never been reported. 
      EXPERIMENTAL DESIGN: Using PCR and primers that amplify MMTV-like gene sequences, 
      we tested cancerous and benign breast tissue from Caucasian-Australian, 
      Vietnamese-Australian, and Vietnamese women. RESULTS: MMTV-like gene sequences 
      were amplified in 19 of 45 (42.2%) archival breast cancer biopsy tissues from 
      Caucasian-Australian women, but only 1 of 120 (0.8%) and 0 of 41 breast cancer 
      biopsy tissues from Vietnamese and Vietnamese-Australian women, respectively. The 
      same sequences were found in only 2 of 111 (1.8%) and 0 of 60 normal (benign) 
      breast tissue samples from Australian and Vietnamese women, respectively. 
      CONCLUSIONS: MMTV-like gene sequences are found in only some human populations 
      and are rarely found in normal human breast tissue from all populations, 
      suggesting they are not present in the normal human genome and have been 
      acquired.
FAU - Ford, Caroline E
AU  - Ford CE
AD  - Virology Division, Department of Microbiology, South Eastern Sydney Area 
      Laboratory Services, The Prince of Wales Hospital, Randwick, NSW 2031, Australia.
FAU - Tran, Dinh
AU  - Tran D
FAU - Deng, YiMo
AU  - Deng Y
FAU - Ta, Van To
AU  - Ta VT
FAU - Rawlinson, William D
AU  - Rawlinson WD
FAU - Lawson, James S
AU  - Lawson JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
SB  - IM
CIN - Clin Cancer Res. 2004 Jan 15;10(2):802. PMID: 14760104
MH  - Asian People
MH  - Australia
MH  - Breast/virology
MH  - Breast Neoplasms/*genetics/virology
MH  - Female
MH  - Genome
MH  - Humans
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Vietnam
MH  - White People
EDAT- 2003/03/13 04:00
MHDA- 2003/10/04 05:00
CRDT- 2003/03/13 04:00
PHST- 2003/03/13 04:00 [pubmed]
PHST- 2003/10/04 05:00 [medline]
PHST- 2003/03/13 04:00 [entrez]
PST - ppublish
SO  - Clin Cancer Res. 2003 Mar;9(3):1118-20.