PMID- 12634097
OWN - NLM
STAT- MEDLINE
DCOM- 20030821
LR  - 20190901
IS  - 0021-9975 (Print)
IS  - 0021-9975 (Linking)
VI  - 128
IP  - 2-3
DP  - 2003 Feb-Apr
TI  - The pathogenicity of diminazene aceturate-resistant Trypanosoma brucei in rats 
      after treatment with the drug.
PG  - 188-91
AB  - Four groups (A, B, C and D) of 10 rats were used to determine the effect of 
      comparatively high doses of diminazene aceturate on diminazene 
      aceturate-resistant Trypanosoma brucei and the pathogenic effect of relapse 
      infection. Group A rats were uninfected (controls) while group B, C and D rats 
      were inoculated intraperitoneally with 0.5 x 10 (6) diminazene 
      aceturate-resistant T. brucei and treated with diminazene aceturate at 14.0, 17.5 
      and 21.0mg/kg body weight, respectively, on day 14 post-infection (PI) as a 
      single intraperitoneal injection. Prepatent periods and also levels of 
      parasitaemia were comparable in groups B, C and D. Packed cell volume (PCV) 
      decreased in the infected groups by day 14 PI and returned to pre-infection 
      values by day 63 post-treatment (PT). Anaemia was comparable in groups B, C and 
      D. Relapse parasitaemia occurred in six rats in group B on day 70 PT and in five 
      rats in each of groups C and D on day 77 PT. The PCV of the rats with relapse 
      infection decreased progressively up to day 105 PT, when the experiment was 
      terminated, whereas the PCV of rats without relapse did not. The levels of 
      anaemia and parasitaemia on day 14 post-relapse were significantly higher 
      (P<0.05) than the levels obtained on day 14 PI in the same animals. Thus, 
      comparatively high doses of diminazene aceturate failed to cure drug-resistant T. 
      brucei infection in 50-60% of infected rats and relapse infections were more 
      severe than the primary infections before treatment.
FAU - Egbe-Nwiyi, T N
AU  - Egbe-Nwiyi TN
AD  - Department of Veterinary Pathology, University of Maiduguri, P.M.B. 1069, 
      Maiduguri, Borno State, Nigeria.
FAU - Igbokwe, I O
AU  - Igbokwe IO
FAU - Onyeyili, P A
AU  - Onyeyili PA
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
RN  - 0 (Trypanocidal Agents)
RN  - JI8SAD85NO (diminazene aceturate)
RN  - Y5G36EEA5Z (Diminazene)
SB  - IM
MH  - Animals
MH  - Diminazene/*analogs & derivatives/*therapeutic use
MH  - Disease Models, Animal
MH  - Dose-Response Relationship, Drug
MH  - Drug Resistance
MH  - Erythrocytes/drug effects/pathology
MH  - Female
MH  - Hematocrit
MH  - Male
MH  - Parasitemia/drug therapy
MH  - Rats
MH  - Recurrence
MH  - Trypanocidal Agents/*therapeutic use
MH  - Trypanosoma brucei brucei/drug effects/*pathogenicity
MH  - Trypanosomiasis, African/*drug therapy
EDAT- 2003/03/14 04:00
MHDA- 2003/08/22 05:00
CRDT- 2003/03/14 04:00
PHST- 2003/03/14 04:00 [pubmed]
PHST- 2003/08/22 05:00 [medline]
PHST- 2003/03/14 04:00 [entrez]
AID - S0021997502905992 [pii]
AID - 10.1053/jcpa.2002.0599 [doi]
PST - ppublish
SO  - J Comp Pathol. 2003 Feb-Apr;128(2-3):188-91. doi: 10.1053/jcpa.2002.0599.