PMID- 12634732
OWN - NLM
STAT- MEDLINE
DCOM- 20031009
LR  - 20041117
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 31
IP  - 5
DP  - 2003 Mar
TI  - Refractory Evans' syndrome treated with allogeneic SCT followed by DLI. 
      Demonstration of a graft-versus-autoimmunity effect.
PG  - 399-402
AB  - Evans' syndrome, a combination of autoimmune haemolytic anaemia and autoimmune 
      (idiopathic) thrombocytopenic purpura, is generally harder to treat and more 
      refractory than the single entities. In a male patient with refractory disease, 
      predominantly thrombocytopenic, an allogeneic reduced intensity BMT from his 
      human leukocyte antigen (HLA)-identical sister was followed by a dramatic 
      platelet peak while he was still experiencing initial engraftment (presumably of 
      autologous origin), but subsequently by progressive relapse associated with mixed 
      chimerism. Five gradually incremental DLI achieved complete donor chimerism, 
      which was associated not only with grade II graft-versus-host disease (GVHD), but 
      also with complete clinical and biological remission for 2 years post-transplant. 
      Long-term FU is necessary before claiming that allogeneic stem cell 
      transplantation (SCT) is capable of curing an autoimmune blood disease. However, 
      there is evidence for a graft-versus-autoimmunity effect in this case.
FAU - Marmont, A M
AU  - Marmont AM
AD  - Department of Hemato-Oncology, St Martino's Hospital, Genova, Italy.
FAU - Gualandi, F
AU  - Gualandi F
FAU - Van Lint, M T
AU  - Van Lint MT
FAU - Bacigalupo, A
AU  - Bacigalupo A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - Anemia, Hemolytic, Autoimmune/immunology/*therapy
MH  - *Autoimmunity
MH  - Graft vs Host Disease/*etiology/immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Lymphocyte Transfusion
MH  - Male
MH  - Purpura, Thrombocytopenic, Idiopathic/immunology/*therapy
MH  - *Tissue Donors
MH  - Transplantation, Homologous
EDAT- 2003/03/14 04:00
MHDA- 2003/10/10 05:00
CRDT- 2003/03/14 04:00
PHST- 2003/03/14 04:00 [pubmed]
PHST- 2003/10/10 05:00 [medline]
PHST- 2003/03/14 04:00 [entrez]
AID - 1703833 [pii]
AID - 10.1038/sj.bmt.1703833 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2003 Mar;31(5):399-402. doi: 10.1038/sj.bmt.1703833.