PMID- 12635573
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20191210
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 24
IP  - 1
DP  - 2003 Jan-Feb
TI  - Hypersensitivity to molds in New York City in adults who have asthma.
PG  - 13-8
AB  - Molds have been linked epidemiologically to asthma as a key aeroallergen in 
      several studies. Other allergens such as cockroach have been linked to asthma in 
      New York City (NYC). To our knowledge, however, the pattern of mold 
      hypersensitivity has never been examined systematically in the NYC area. Thus, we 
      sought to determine the association between mold hypersensitivity and asthma in a 
      large group of ambulatory patients evaluated for allergic disease for the years 
      1993 through 2001 at a single medical center. Serological testing for 
      mold-specific immunoglobulin E (IgE) as well as IgE specific for other 
      aeroallergens was performed and the associations between allergen-specific IgE 
      and the presence of asthma were examined using bivariate and multivariate 
      analysis. Factor analysis showed that three distinct groupings of 
      aeroallergen-specific IgE existed within the panel of allergens used. Group 1 
      consisted of cat dander and dust mites (Dermatophagoides farinae). Group 2 
      consisted of tree, grass, and ragweed pollen. Group 3 consisted of the 
      Deuteromycetes molds, Alternaria tenuis, Aspergillus fumigatus, and Cladosporium 
      herbarum. Patients with asthma had a highly significant increase in the incidence 
      of hypersensitivity to cat/dust mites and to the molds. Multivariate analysis 
      showed that the presence of hypersensitivity to either A. tenuis or C. herbarum 
      had a significant independent association with asthma after adjustment for 
      cat/dust mite hypersensitivity and after adjustment for other clinical factors. 
      On the other hand, pollen hypersensitivity was not associated independently with 
      asthma. Mold hypersensitivity was strongly correlated with hypersensitivity to 
      cat or dust mites in patients who did not have asthma but not in patients who did 
      have asthma. In the NYC area, recent pollen and spore counts show that mold 
      spores are measurable in at least 75% of the year. Thus it is conceivable that 
      mold hypersensitivity plays a contributing and independent role in initiating or 
      perpetuating the allergic response in patients with asthma in the New York area.
FAU - Lin, Robert Y
AU  - Lin RY
AD  - Department of Medicine, Saint Vincents Hospital, Manhattan, USA.
FAU - Williams, Karlene D
AU  - Williams KD
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Air Pollutants)
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Air Pollutants/adverse effects/immunology
MH  - Allergens/*adverse effects/*immunology
MH  - Ambrosia/adverse effects/immunology
MH  - Analysis of Variance
MH  - Animals
MH  - Asthma/etiology/immunology/metabolism
MH  - Cats
MH  - Cockroaches/immunology
MH  - Dactylis/adverse effects/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology/metabolism
MH  - Logistic Models
MH  - Male
MH  - Mice/immunology/urine
MH  - Mitosporic Fungi/*immunology
MH  - Multivariate Analysis
MH  - New York City/epidemiology
MH  - Pollen/adverse effects/immunology
MH  - Predictive Value of Tests
MH  - Pyroglyphidae/immunology
MH  - Radioallergosorbent Test
MH  - Respiratory Hypersensitivity/*etiology/immunology/metabolism
MH  - Rhinitis, Allergic, Perennial/etiology/immunology
MH  - Risk Factors
MH  - Spores, Fungal/immunology
MH  - Statistics as Topic
EDAT- 2003/03/15 04:00
MHDA- 2003/07/26 05:00
CRDT- 2003/03/15 04:00
PHST- 2003/03/15 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2003/03/15 04:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2003 Jan-Feb;24(1):13-8.