PMID- 12636945
OWN - NLM
STAT- MEDLINE
DCOM- 20030403
LR  - 20190818
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 101
IP  - 3
DP  - 2003 Mar
TI  - Immunogenetic correlates for Chlamydia trachomatis-associated tubal infertility.
PG  - 438-44
AB  - OBJECTIVE: To understand immunogenetic mechanisms of Chlamydia trachomatis 
      infection and tubal scarring. METHODS: We measured and compared previously 
      significant human leukocyte antigen (HLA) class II DQ alleles, their linked DRB 
      genes, and polymorphisms in selected cytokine genes (tumor necrosis factor 
      alpha-308 promoter; transforming growth factor beta1-10 and -25 codons; 
      interleukin 10-1082, -819, and -592 promoters; interleukin 6-174 promoter; and 
      interferon gamma+874 codon 1) among Kenyan women with confirmed tubal infertility 
      with and without C trachomatis microimmunofluorescence antibody. RESULTS: Two 
      class II alleles, HLA-DR1*1503 and DRB5*0101, were detected less commonly in C 
      trachomatis microimmunofluorescence seropositive women than in C trachomatis 
      microimmunofluorescence seronegative women with infertility (0% versus 20%; odds 
      ratio [OR] 0.05; 95% confidence interval [CI] 0, 0.7, and 6% versus 26%; OR 0.2; 
      95% CI 0.02, 1.0, respectively). These alleles are commonly linked as a haplotype 
      at the DRB locus. This finding could not be explained through linkage 
      disequilibrium with the other studied HLA or cytokine genes. CONCLUSION: These 
      alleles may lead to an immunologically mediated mechanism of protection against C 
      trachomatis infection and associated tubal damage, or alternatively increase risk 
      for tubal scarring due to another cause.
FAU - Cohen, Craig R
AU  - Cohen CR
AD  - Departments of Obstetrics and Gynecology, University of Washington, Box 356460, 
      Seattle, WA 98195, USA. crcohen@u.washington.edu
FAU - Gichui, Joseph
AU  - Gichui J
FAU - Rukaria, Rachel
AU  - Rukaria R
FAU - Sinei, Samuel S
AU  - Sinei SS
FAU - Gaur, Lakshmi K
AU  - Gaur LK
FAU - Brunham, Robert C
AU  - Brunham RC
LA  - eng
GR  - AI 31448/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antibodies, Bacterial/blood
MH  - Chlamydia Infections/*immunology
MH  - Chlamydia trachomatis/*immunology/isolation & purification
MH  - Cytokines/*genetics
MH  - Fallopian Tube Diseases/*microbiology
MH  - Female
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Infertility, Female/*microbiology
MH  - Kenya
MH  - Polymorphism, Genetic
EDAT- 2003/03/15 04:00
MHDA- 2003/04/04 05:00
CRDT- 2003/03/15 04:00
PHST- 2003/03/15 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2003/03/15 04:00 [entrez]
AID - S0029784402030776 [pii]
AID - 10.1016/s0029-7844(02)03077-6 [doi]
PST - ppublish
SO  - Obstet Gynecol. 2003 Mar;101(3):438-44. doi: 10.1016/s0029-7844(02)03077-6.