PMID- 12639724
OWN - NLM
STAT- MEDLINE
DCOM- 20030428
LR  - 20190724
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 208
IP  - 1-2
DP  - 2003 Apr 15
TI  - Changes in serum macrophage-related factors in patients with chronic inflammatory 
      demyelinating polyneuropathy caused by intravenous immunoglobulin therapy.
PG  - 43-50
AB  - Chronic inflammatory demyelinating polyneuropathy (CIDP) is a slowly progressive 
      or recurrent neuropathy accompanied by infiltration of macrophages in the 
      peripheral nerves. Macrophage colony-stimulating factor (M-CSF) and monocyte 
      chemoattractant protein-1 (MCP-1) are a macrophage-related cytokine and 
      chemokine, respectively. Although, intravenous immunoglobulin (IVIg) infusion 
      therapy has been used for treating CIDP patients, not all CIDP patients have 
      responded to IVIg infusion therapy. To determine the mechanisms of the action of 
      IVIg, we examined serum M-CSF and MCP-1 levels during and after IVIg infusion 
      therapy in 19 CIDP patients treated with IVIg (0.4 g/kg/day for 5 days). Ten of 
      the 19 patients (52.6%) responded to IVIg therapy. Both M-CSF and MCP-1 
      concentrations in IVIg responders were significantly higher on day 1 postinfusion 
      than those in nonresponders, but decreased to their pretreatment values on day 5 
      postinfusion. The results suggest that immunomodulation through M-CSF and MCP-1 
      is involved in the mechanisms underlying the effect of IVIg infusion therapy in 
      CIDP patients.
FAU - Ochi, Kazuhide
AU  - Ochi K
AD  - Department of Clinical Neuroscience and Therapeutics, Division of Integrated 
      Medical Science, Programs for Biomedical Research, Graduate School of Biomedical 
      Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Japan. 
      kazuhide@hiroshima-u.ac.jp
FAU - Kohriyama, Tatsuo
AU  - Kohriyama T
FAU - Higaki, Masahiro
AU  - Higaki M
FAU - Ikeda, Junko
AU  - Ikeda J
FAU - Harada, Akira
AU  - Harada A
FAU - Nakamura, Shigenobu
AU  - Nakamura S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Chemokine CCL2)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/administration & dosage/therapeutic use
MH  - Macrophage Activation
MH  - Macrophage Colony-Stimulating Factor/*blood
MH  - Macrophages/immunology
MH  - Male
MH  - Middle Aged
MH  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/*blood/therapy
MH  - Time Factors
EDAT- 2003/03/18 04:00
MHDA- 2003/04/29 05:00
CRDT- 2003/03/18 04:00
PHST- 2003/03/18 04:00 [pubmed]
PHST- 2003/04/29 05:00 [medline]
PHST- 2003/03/18 04:00 [entrez]
AID - S0022510X02004227 [pii]
AID - 10.1016/s0022-510x(02)00422-7 [doi]
PST - ppublish
SO  - J Neurol Sci. 2003 Apr 15;208(1-2):43-50. doi: 10.1016/s0022-510x(02)00422-7.