PMID- 12639747
OWN - NLM
STAT- MEDLINE
DCOM- 20030630
LR  - 20190901
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 85
IP  - 2-3
DP  - 2003 Apr
TI  - Effect of T. foenumgraecum on glycogen content of tissues and the key enzymes of 
      carbohydrate metabolism.
PG  - 237-42
AB  - The Indian traditional system of medicine prescribed plant therapies for diseases 
      including diabetes mellitus called madhumeh in Sanskrit. One such plant mentioned 
      in Ayurveda is Trigonella foenumgraecum (FG). In the present study, FG (1g/kg PO) 
      was assessed for its effect on glycogen levels of insulin dependent (skeletal 
      muscle and liver), insulin independent tissues (kidneys and brain) and enzymes 
      such as glucokinase (GK), hexokinase (HK), and phosphofructokinase (PFK). 
      Administration of FG led to decrease in blood glucose levels by 14.4 and 46.64% 
      on 15th and 30th day of the experiment. Liver and 2-kidney weight expressed as 
      percentage of body weight was significantly increased in diabetics (P<0.0005) 
      versus normal controls and this alteration in the renal weight (P<0.0005) but not 
      liver weight was normalized by feeding of FG. Renal glycogen content increased by 
      over 10 folds while hepatic and skeletal muscle glycogen content decreased by 75 
      and 68% in diabetic controls versus controls and these alteration in glycogen 
      content was partly prevented by FG. Activity of HK, GK and PFK in diabetic 
      controls was 35, 50 and 60% of the controls and FG partially corrected this 
      alteration in PFK, HK and GK.
FAU - Vats, V
AU  - Vats V
AD  - Department of Pharmacology, All India Institute of Medical Sciences, Ansari 
      Nagar, 110049, New Delhi, India.
FAU - Yadav, S P
AU  - Yadav SP
FAU - Grover, J K
AU  - Grover JK
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Blood Glucose)
RN  - 0 (Plant Extracts)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.7.1 - (Phosphofructokinases)
RN  - EC 2.7.1.2 (Glucokinase)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight/drug effects
MH  - Bone and Bones/drug effects/enzymology
MH  - *Carbohydrate Metabolism
MH  - Diabetes Mellitus, Experimental/metabolism
MH  - Glucokinase/metabolism
MH  - Glycogen/*metabolism
MH  - India
MH  - Kidney/drug effects
MH  - Liver/drug effects/enzymology
MH  - Male
MH  - Medicine, Ayurvedic
MH  - Organ Size/drug effects
MH  - Phosphofructokinases/metabolism
MH  - Plant Extracts/pharmacology
MH  - Rats
MH  - Tissue Distribution
MH  - Trigonella/*chemistry
EDAT- 2003/03/18 04:00
MHDA- 2003/07/02 05:00
CRDT- 2003/03/18 04:00
PHST- 2003/03/18 04:00 [pubmed]
PHST- 2003/07/02 05:00 [medline]
PHST- 2003/03/18 04:00 [entrez]
AID - S0378874103000229 [pii]
AID - 10.1016/s0378-8741(03)00022-9 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2003 Apr;85(2-3):237-42. doi: 10.1016/s0378-8741(03)00022-9.