PMID- 12640204
OWN - NLM
STAT- MEDLINE
DCOM- 20030423
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 32
IP  - 4
DP  - 2003 Apr 1
TI  - A cluster of human T-cell lymphotropic virus type I-associated 
      myelopathy/tropical spastic paraparesis in Jujuy, Argentina.
PG  - 441-5
AB  - Compared with other regions in Argentina, greater human T-cell lymphotropic virus 
      type I (HTLV-I) seroprevalence has been reported in Jujuy Province, where it 
      reaches 2.32% in the general population, so that a search for HTLV-I-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP) cases deserved to be carried 
      out. Accordingly, a clinically diagnosed and serologically confirmed cluster of 
      cases in 1 man and 10 women, including 2 sisters, is described here. Most 
      patients (9/11) were born in Cochinoca Department, located in an Andes highland 
      area called Puna Jujena, situated at more that 3400 m above sea level. No history 
      of risk factors was disclosed, except for a single transfusion in 1 patient. In 
      contrast to the Andean region of Bolivia, where high HTLV-I seroprevalence is in 
      part attributable to Japanese immigrants, the Jujuy population mainly consists of 
      aborigines, mestizos, and European descendants. Therefore, the long-term presence 
      of virus in Jujuy natives may be taken for granted. Considering the HAM/TSP 
      cluster described here plus previously reported isolated cases in neighboring 
      Salta Province, we speculate that the Puna Jujena region and regions in that 
      vicinity would be a microepidemic focus of disease. To determine the role of 
      possible pathogenic cofactors such as geographic, ethnic, genetic, and cultural 
      features, further pertinent surveys are required in subtropical northwestern 
      Argentina.
FAU - Biglione, Mirna M
AU  - Biglione MM
AD  - National Reference Center of AIDS, Buenos Aires, Argentina. mbiglione@fmed.uba.ar
FAU - Pizarro, Manuel
AU  - Pizarro M
FAU - Puca, Alberto
AU  - Puca A
FAU - Salomon, Horacio E
AU  - Salomon HE
FAU - Berria, Maria I
AU  - Berria MI
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
SB  - IM
MH  - Argentina/epidemiology
MH  - Cluster Analysis
MH  - Disease Outbreaks
MH  - Female
MH  - Geography
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Paraparesis, Tropical Spastic/complications/*epidemiology
MH  - Siblings
MH  - Surveys and Questionnaires
EDAT- 2003/03/18 04:00
MHDA- 2003/04/24 05:00
CRDT- 2003/03/18 04:00
PHST- 2003/03/18 04:00 [pubmed]
PHST- 2003/04/24 05:00 [medline]
PHST- 2003/03/18 04:00 [entrez]
AID - 10.1097/00126334-200304010-00015 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2003 Apr 1;32(4):441-5. doi: 
      10.1097/00126334-200304010-00015.