PMID- 12640319
OWN - NLM
STAT- MEDLINE
DCOM- 20030410
LR  - 20131121
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 75
IP  - 5
DP  - 2003 Mar 15
TI  - Unusual onset of chronic graft-versus-host disease after adult living-related 
      liver transplantation from a homozygous donor.
PG  - 733-6
AB  - Graft-versus-host disease (GVHD) is a rare complication that occurs after 
      living-related liver transplantation (LRLT). This condition usually occurs early 
      after transplantation and is fatal. Although one-way matching between a human 
      leukocyte antigen (HLA)-homozygous donor and a haploidentical recipient has been 
      shown to be a significant risk factor for the development of acute GVHD, chronic 
      GVHD has not been clarified. A 50-year-old woman underwent LRLT for primary 
      biliary cirrhosis with her 32-year-old HLA-homozygous son as the donor. The 
      patient developed chronic GVHD 114 days posttransplant, presenting with a skin 
      rash only. Her atypical onset included neither fever nor gastrointestinal 
      symptoms. The patient responded to corticosteroid therapy and is now doing well 
      at home. Careful donor selection and HLA matching before LRLT should be performed 
      to prevent GVHD. However, the risks associated with grafts from homozygous donors 
      may be unavoidable at present because of the shortage of cadaveric donors in 
      Japan.
FAU - Nemoto, Takehiko
AU  - Nemoto T
AD  - Liver Transplant Team, Department of Surgery, Dokkyo University School of 
      Medicine, Tochigi, Japan. t-nemoto@dokkyomed.ac.jp
FAU - Kubota, Keiichi
AU  - Kubota K
FAU - Kita, Junji
AU  - Kita J
FAU - Shimoda, Mitsugi
AU  - Shimoda M
FAU - Rokkaku, Kyu
AU  - Rokkaku K
FAU - Tagaya, Nobumi
AU  - Tagaya N
FAU - Fujiwara, Toshio
AU  - Fujiwara T
FAU - Sunakawa, Masakatsu
AU  - Sunakawa M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Glucocorticoids)
RN  - 0 (HLA Antigens)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Chronic Disease
MH  - Dermatitis/*etiology
MH  - Female
MH  - Glucocorticoids/administration & dosage
MH  - *Graft vs Host Disease/*complications/drug therapy
MH  - HLA Antigens/*genetics
MH  - *Homozygote
MH  - Humans
MH  - Liver Cirrhosis, Biliary/surgery
MH  - *Liver Transplantation
MH  - *Living Donors
MH  - Male
MH  - Methylprednisolone/administration & dosage
MH  - Middle Aged
EDAT- 2003/03/18 04:00
MHDA- 2003/04/11 05:00
CRDT- 2003/03/18 04:00
PHST- 2003/03/18 04:00 [pubmed]
PHST- 2003/04/11 05:00 [medline]
PHST- 2003/03/18 04:00 [entrez]
AID - 10.1097/01.TP.0000053401.91094.CA [doi]
PST - ppublish
SO  - Transplantation. 2003 Mar 15;75(5):733-6. doi: 10.1097/01.TP.0000053401.91094.CA.