PMID- 12641658
OWN - NLM
STAT- MEDLINE
DCOM- 20030411
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 57
IP  - 3
DP  - 2003 Mar
TI  - A correlation between migraine, histamine and immunoglobulin e.
PG  - 286-90
AB  - Although migraine affects about 15% of population and many studies have been 
      performed to find the mechanism and a successful management, the physiopathology 
      of migraine is still largely unknown. The possibility of an immunoglobulin E 
      (IgE)-mediated allergic mechanism and the role of histamine remain controversial. 
      The aim of the present study was to evaluate serum total IgE and histamine levels 
      in migraine patients and the influence of allergy on them. Seventy patients 
      (18-58 years) with migraine without aura were divided into two groups according 
      to their history of allergy (60% with and 40% without allergy). Serum samples 
      were collected during fasting without allowing any premedication during the two 
      periods of attack and remission. There was a control group containing 45 healthy 
      volunteers. Serum total IgE and histamine levels were measured by enzyme-linked 
      immunosorbent assay and fluorimetric methods, respectively. Mean and standard 
      errors of serum histamine (ng/ml) and total IgE (IU/ml) levels were found in the 
      control group to be 48.16 +/- 2.70 and 38.31 +/- 3.20, in the migraine with 
      allergy group 159.11 +/- 4.60 and 303.30 +/- 42.50 and in the migraine without 
      allergy group 105.01 +/- 8.50 and 79.07 +/- 2.70, respectively. Total IgE levels 
      in migraine with allergy group were found to be significantly (P < 0.0001) above 
      that in the control and another group, suggesting an influence of an IgE-mediated 
      mechanism on migraine. Although the plasma histamine levels, which were 
      significantly elevated (P < 0.0001) in patients with migraine, both during 
      headache and symptom-free periods, when compared with the control group, indicate 
      that there is an increased susceptibility to histamine in allergic conditions, 
      this molecule has also an unrelated role in migraine. The relationship between 
      allergy and migraine can be based, in part, on an IgE-mediated mechanism, and 
      histamine release plays an important role. Thus, the avoidance of allergic 
      conditions in migraine patients may be a simple, helpful way for prophylaxis or 
      their treatment.
FAU - Gazerani, P
AU  - Gazerani P
AD  - Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Pourpak, Z
AU  - Pourpak Z
FAU - Ahmadiani, A
AU  - Ahmadiani A
FAU - Hemmati, A
AU  - Hemmati A
FAU - Kazemnejad, A
AU  - Kazemnejad A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Histamine/*blood
MH  - Humans
MH  - Hypersensitivity/immunology
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/blood/*immunology
MH  - Statistics, Nonparametric
EDAT- 2003/03/19 04:00
MHDA- 2003/04/12 05:00
CRDT- 2003/03/19 04:00
PHST- 2003/03/19 04:00 [pubmed]
PHST- 2003/04/12 05:00 [medline]
PHST- 2003/03/19 04:00 [entrez]
AID - 1216 [pii]
AID - 10.1046/j.1365-3083.2003.01216.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2003 Mar;57(3):286-90. doi: 10.1046/j.1365-3083.2003.01216.x.