PMID- 12644030
OWN - NLM
STAT- MEDLINE
DCOM- 20030408
LR  - 20191106
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 98
IP  - 3 Suppl
DP  - 2003 Mar
TI  - Intermittent and on-demand use of proton pump inhibitors in the management of 
      symptomatic gastroesophageal reflux disease.
PG  - S40-8
AB  - The epidemic of gastroesophageal reflux disease (GERD) in industrialized nations 
      is currently spreading to less-developed ones, with more than half of the 
      patients having symptomatic or mild erosive GERD. The long-term management of 
      GERD has been dominated by daily maintenance treatment with proton pump 
      inhibitors (PPI) to prevent relapse. It is common, however, for many patients 
      with mild disease and infrequent symptom relapses to use a PPI only when symptoms 
      demand. Patients with symptomatic or mild erosive GERD are therefore ideal for 
      on-demand or intermittent treatment. The efficacy of such a strategy of 
      intermittent treatment, or treatment of symptoms on demand, has recently been 
      evaluated in four randomized controlled studies. These trials demonstrate that 
      such therapeutic strategies reduce symptoms, improve quality of life, and are 
      cost effective. In clinical practice, the author has found these treatment 
      strategies suitable for approximately 60% of newly diagnosed patients with GERD 
      for the long-term management of symptomatic GERD of mild or moderate severity.
FAU - Bardhan, Karna Dev
AU  - Bardhan KD
AD  - Rotherham General Hospitals NHS Trust, Moorgate Road, Rotherham S60 2UD, United 
      Kingdom.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Ulcer Agents/*administration & dosage/pharmacokinetics
MH  - Enzyme Inhibitors/*administration & dosage/pharmacokinetics
MH  - Esophagitis, Peptic/drug therapy
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - *Proton Pump Inhibitors
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
RF  - 50
EDAT- 2003/03/20 04:00
MHDA- 2003/04/09 05:00
CRDT- 2003/03/20 04:00
PHST- 2003/03/20 04:00 [pubmed]
PHST- 2003/04/09 05:00 [medline]
PHST- 2003/03/20 04:00 [entrez]
AID - S0002927003000145 [pii]
AID - 10.1016/s0002-9270(03)00014-5 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2003 Mar;98(3 Suppl):S40-8. doi: 
      10.1016/s0002-9270(03)00014-5.