PMID- 12644267
OWN - NLM
STAT- MEDLINE
DCOM- 20030604
LR  - 20191210
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 968
IP  - 1
DP  - 2003 Apr 4
TI  - Developmental 3,4-methylenedioxymethamphetamine (MDMA) impairs sequential and 
      spatial but not cued learning independent of growth, litter effects or injection 
      stress.
PG  - 89-101
AB  - Previously, we have shown that rats administered MDMA from postnatal (P) days 
      11-20 had reductions in body weight during the period of treatment and as adults 
      they had deficits in sequential and spatial learning and memory. In the present 
      study, to control for weight reductions, we used litters with double the number 
      of offspring to induce growth restriction comparable to that of standard size 
      litters treated with MDMA. Litters were treated twice daily from P11 to 20 with 
      vehicle or MDMA (20 mg/kg) or only weighed. Males, but not females, exposed to 
      MDMA had longer latencies and more errors in the Cincinnati water maze compared 
      to males of the other treatments. In the Morris water maze (210 cm pool, 10x10 cm 
      platform), the MDMA animals were impaired relative to all other treatments during 
      acquisition. Only the MDMA females showed deficits when the platform was shifted 
      to a new location, however, both MDMA males and females were impaired when the 
      location of the platform was again shifted and a reduced platform (5x5 cm) used. 
      No differences were observed in the ability to swim a straight channel, locate a 
      platform with a cue, or the endocrine response to forced swim among the treatment 
      groups. No differences were seen between animals injected with saline and those 
      only weighed. The data suggest that factors, such as growth retardation, multiple 
      injections, or the composition of the litter, do not affect the development of 
      learning and memory impairments resulting from P11 to 20 MDMA exposure. The large 
      litter approach offers a novel method to control for undernutrition during the 
      preweaning period in rodents.
FAU - Williams, Michael T
AU  - Williams MT
AD  - Pharmacology Research Center, Cincinnati Children's Research Foundation and 
      University of Cincinnati College of Medicine, 45229-3039, Cincinnati, OH, USA
FAU - Morford, LaRonda L
AU  - Morford LL
FAU - Wood, Sandra L
AU  - Wood SL
FAU - Rock, Stephanie L
AU  - Rock SL
FAU - McCrea, Anne E
AU  - McCrea AE
FAU - Fukumura, Masao
AU  - Fukumura M
FAU - Wallace, Tanya L
AU  - Wallace TL
FAU - Broening, Harry W
AU  - Broening HW
FAU - Moran, Mary S
AU  - Moran MS
FAU - Vorhees, Charles V
AU  - Vorhees CV
LA  - eng
GR  - DA11902/DA/NIDA NIH HHS/United States
GR  - ES07051/ES/NIEHS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/*adverse effects/*analogs & 
      derivatives
MH  - Adrenocorticotropic Hormone/blood
MH  - Aging
MH  - Animals
MH  - Animals, Newborn/growth & development
MH  - Behavior, Animal
MH  - Body Constitution
MH  - Body Weight
MH  - Case-Control Studies
MH  - Corticosterone/blood
MH  - Cues
MH  - Excitatory Amino Acid Agonists/administration & dosage/*adverse effects
MH  - Female
MH  - Learning Disabilities/*etiology
MH  - Litter Size/*drug effects/physiology
MH  - Male
MH  - Maze Learning/drug effects
MH  - Parity
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time
MH  - Serial Learning/*drug effects
MH  - Sex Factors
MH  - Spatial Behavior/*drug effects
MH  - Stress, Physiological
MH  - Swimming/physiology
MH  - Time Factors
EDAT- 2003/03/20 04:00
MHDA- 2003/06/05 05:00
CRDT- 2003/03/20 04:00
PHST- 2003/03/20 04:00 [pubmed]
PHST- 2003/06/05 05:00 [medline]
PHST- 2003/03/20 04:00 [entrez]
AID - S0006899302042786 [pii]
AID - 10.1016/s0006-8993(02)04278-6 [doi]
PST - ppublish
SO  - Brain Res. 2003 Apr 4;968(1):89-101. doi: 10.1016/s0006-8993(02)04278-6.