PMID- 12644289
OWN - NLM
STAT- MEDLINE
DCOM- 20030428
LR  - 20190826
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 140
IP  - 1-2
DP  - 2003 Mar 18
TI  - Effects of electrical stimulation or lesion in nucleus accumbens on the behaviour 
      of rats in a T-maze after administration of 8-OH-DPAT or vehicle.
PG  - 165-73
AB  - Electrical brain stimulation may be a therapeutic alternative for irreversible 
      lesions in treatment-resistant patients with obsessive-compulsive disorder (OCD). 
      We compared the effects of electrical stimulation and lesion in the nucleus 
      accumbens (n acc) on the behaviour of rats in a model for OCD. Rats were tested 
      for spontaneous alternation behaviour (AB) in a T-maze and assigned to four 
      groups: an electrode implant group with stimulation 'ON' (stimON) or 'OFF' 
      (stimOFF), a lesion or a sham group. Postoperatively, the number of arm visits 
      and AB were tested after 8-hydroxy-2-(di-n-propylamino)-tetralin hydrobromide 
      (8-OH-DPAT; 2 mg/kg) or saline administration. After 8-OH-DPAT administration, 
      more arm visits were counted in the stimON (92.2%) and lesion groups (79.3%) than 
      in both control groups (stimOFF 54.2; sham 61.2%). AB was significantly decreased 
      in the stimON (10.5%) and lesion groups (10.2%) relative to the sham (22.0%) but 
      not to the stimOFF group (14.7%). After saline administration, rats performed 
      more arm visits in the stimON (81.5% non-significant) and lesion groups (93.6% 
      significant) relative to the stimOFF (70.8%) and the sham groups (74.5%). No 
      significant differences, however, were observed for AB. In conclusion, both 
      treatments resulted in a decreased AB after 8-OH-DPAT administration (modelling 
      an increase in compulsions) and more arm visits.
FAU - van Kuyck, Kris
AU  - van Kuyck K
AD  - Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of 
      Neuroscience and Psychiatry, K.U. Leuven Provisorium 1, Minderbroedersstraat 17, 
      Belgium.
FAU - Demeulemeester, Hilde
AU  - Demeulemeester H
FAU - Feys, Hilde
AU  - Feys H
FAU - De Weerdt, Willy
AU  - De Weerdt W
FAU - Dewil, Maarten
AU  - Dewil M
FAU - Tousseyn, Thomas
AU  - Tousseyn T
FAU - De Sutter, Paul
AU  - De Sutter P
FAU - Gybels, Jan
AU  - Gybels J
FAU - Bogaerts, Kris
AU  - Bogaerts K
FAU - Dom, Rene
AU  - Dom R
FAU - Nuttin, Bart
AU  - Nuttin B
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Pharmaceutical Vehicles)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/*pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Disease Models, Animal
MH  - Electric Stimulation Therapy
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Nucleus Accumbens/injuries/pathology/*physiopathology
MH  - Obsessive-Compulsive Disorder/physiopathology/psychology/surgery/*therapy
MH  - Pharmaceutical Vehicles/administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin Receptor Agonists/*pharmacology
EDAT- 2003/03/20 04:00
MHDA- 2003/04/29 05:00
CRDT- 2003/03/20 04:00
PHST- 2003/03/20 04:00 [pubmed]
PHST- 2003/04/29 05:00 [medline]
PHST- 2003/03/20 04:00 [entrez]
AID - S0166432802002954 [pii]
AID - 10.1016/s0166-4328(02)00295-4 [doi]
PST - ppublish
SO  - Behav Brain Res. 2003 Mar 18;140(1-2):165-73. doi: 10.1016/s0166-4328(02)00295-4.