PMID- 12646282
OWN - NLM
STAT- MEDLINE
DCOM- 20030703
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 44
IP  - 4
DP  - 2003 Mar
TI  - Differential effect of dietary selenium on the long-term neurotoxicity induced by 
      MDMA in mice and rats.
PG  - 449-61
AB  - We examined the effect of dietary selenium (Se) on the long-term effect of 
      3,4-methylenedioxymethamphetamine (MDMA) on dopamine (DA) and 5-hydroxytryptamine 
      (5-HT) containing neurons in the brain of mice and rats. Animals were fed either 
      a Se-deficient (<0.02 ppm) or Se-replete (0.2 ppm) diet for 8 weeks. On the 
      seventh week mice received three injections of MDMA (15 mg/kg, i.p. 3 h apart) or 
      saline and rats a single dose of MDMA (12.5 mg/kg i.p.) or saline. All animals 
      were sacrificed 7 days later. MDMA administration to mice depleted striatal DA 
      concentration in both dietary groups, although depletion was considerably larger 
      in the Se-deficient mice (64%) than Se-replete mice (30%). In addition, a 
      decrease in 5-HT (17-32%) occurred in brain regions of Se-deficient but not 
      Se-replete mice. In rats, MDMA decreased cortical [(3)H]-paroxetine binding (62%) 
      and 5-HT content, the depletion being similar in the Se-deficient and Se-replete 
      groups. No DA loss occurred in either group. There was no difference in the 
      hyperthermic response induced by MDMA in Se-deficient or Se-replete animals. The 
      Se-deficient diet decreased glutathione peroxidase (GPx) activity by 30% in mouse 
      striatum and cortex and increased the degree of lipid peroxidation in cortical 
      synaptosomes. Se-deficient rats also showed a decrease in brain GPx activity 
      compared with the Se-replete group, but the degree of lipid peroxidation in 
      synaptosomes was similar in both dietary groups. These results suggest that the 
      antioxidant capacity of rats and mice differ leading to a differential 
      susceptibility to the oxidative stress caused by MDMA in situations of low 
      dietary Se.
FAU - Sanchez, V
AU  - Sanchez V
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad Complutense, 
      Madrid 28040, Spain.
FAU - Camarero, J
AU  - Camarero J
FAU - O'Shea, E
AU  - O'Shea E
FAU - Green, A R
AU  - Green AR
FAU - Colado, M I
AU  - Colado MI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 333DO1RDJY (Serotonin)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - H6241UJ22B (Selenium)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Body Temperature/drug effects
MH  - Brain/drug effects/metabolism
MH  - Diet
MH  - Dopamine/metabolism
MH  - Drug Synergism
MH  - Eating/drug effects
MH  - Glutathione Peroxidase/metabolism
MH  - In Vitro Techniques
MH  - Lipid Peroxidation/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Rats
MH  - Selenium/administration & dosage/deficiency/*toxicity
MH  - Serotonin/metabolism
MH  - Species Specificity
MH  - Weight Gain/drug effects
EDAT- 2003/03/21 04:00
MHDA- 2003/07/04 05:00
CRDT- 2003/03/21 04:00
PHST- 2003/03/21 04:00 [pubmed]
PHST- 2003/07/04 05:00 [medline]
PHST- 2003/03/21 04:00 [entrez]
AID - S0028390802004112 [pii]
AID - 10.1016/s0028-3908(02)00411-2 [doi]
PST - ppublish
SO  - Neuropharmacology. 2003 Mar;44(4):449-61. doi: 10.1016/s0028-3908(02)00411-2.