PMID- 12646943
OWN - NLM
STAT- MEDLINE
DCOM- 20030516
LR  - 20130304
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 17
IP  - 3
DP  - 2003 Mar
TI  - Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic 
      leukemia: a study of 20 cases.
PG  - 547-53
AB  - This study identifies multiple copies of the AML1 gene on a duplicated chromosome 
      21, dup(21), as a recurrent abnormality in acute lymphoblastic leukemia (ALL). 
      Clusters of AML1 signals were visible at interphase by fluorescence in situ 
      hybridization (FISH). In metaphase, they appeared tandemly duplicated on marker 
      chromosomes of five distinct morphological types: large or small acrocentrics, 
      metacentrics, submetacentrics or rings. The markers comprised only chromosome 21 
      material. Karyotypes were near-diploid and, besides dup(21), no other established 
      chromosomal changes were observed. A total of 20 patients, 1.5 and <0.5% among 
      consecutive series of childhood and adult ALL respectively, showed this 
      phenomenon. Their median age was 9 years, white cell counts were low and all had 
      a pre-B/common immunophenotype. Although this series is not the first report of 
      this abnormality, it is the largest, permitting a detailed description of the 
      variety of morphological forms that duplicated chromosome 21 can assume.
FAU - Harewood, L
AU  - Harewood L
AD  - Leukaemia Research Fund Cytogenetics Group, Cancer Sciences Division, University 
      of Southampton, UK.
FAU - Robinson, H
AU  - Robinson H
FAU - Harris, R
AU  - Harris R
FAU - Al-Obaidi, M Jabbar
AU  - Al-Obaidi MJ
FAU - Jalali, G R
AU  - Jalali GR
FAU - Martineau, M
AU  - Martineau M
FAU - Moorman, A V
AU  - Moorman AV
FAU - Sumption, N
AU  - Sumption N
FAU - Richards, S
AU  - Richards S
FAU - Mitchell, C
AU  - Mitchell C
FAU - Harrison, C J
AU  - Harrison CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 21
MH  - Core Binding Factor Alpha 2 Subunit
MH  - DNA-Binding Proteins/*genetics
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Karyotyping
MH  - Middle Aged
MH  - Ploidies
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/mortality
MH  - *Proto-Oncogene Proteins
MH  - Survival Rate
MH  - Transcription Factors/*genetics
RF  - 29
EDAT- 2003/03/21 04:00
MHDA- 2003/05/17 05:00
CRDT- 2003/03/21 04:00
PHST- 2003/03/21 04:00 [pubmed]
PHST- 2003/05/17 05:00 [medline]
PHST- 2003/03/21 04:00 [entrez]
AID - 2402849 [pii]
AID - 10.1038/sj.leu.2402849 [doi]
PST - ppublish
SO  - Leukemia. 2003 Mar;17(3):547-53. doi: 10.1038/sj.leu.2402849.