PMID- 12647220
OWN - NLM
STAT- MEDLINE
DCOM- 20030509
LR  - 20161124
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 442
IP  - 3
DP  - 2003 Mar
TI  - Expression patterns of transcription factors in progressively transformed 
      germinal centers and Hodgkin lymphoma.
PG  - 284-93
AB  - The World Health Organization (WHO) classification of Hodgkin lymphoma (HL) 
      distinguishes two types: Classical Hodgkin lymphoma (CHL) and nodular lymphocyte 
      predominant Hodgkin lymphoma (NLPHL). Both groups have in common that they mostly 
      derive from B cells with rare classical cases originating from T cells. They 
      differ in their histomorphology, immunophenotype, and clinical behavior. One of 
      the subtypes of CHL, designated as lymphocyte-rich classical Hodgkin lymphoma 
      (LRCHL), shares some morphological features with NLPHL. The transcription factors 
      BSAP, BOB.1, Oct2 and MUM1 are sequentially expressed in normal B-cell 
      development. In order to investigate the relationship between the CHL subgroups 
      and NLPHL, we examined the protein expression of these transcription factors 
      using immunohistochemistry in 15 reactive processes and 4 different subtypes of 
      58 HL cases. Our findings underline the B-cell origin of HL, without evidence, 
      that reactive processes like progressively transformed germinal centers (PTGCs) 
      are precursor lesions of HL. Furthermore, they demonstrate that LRCHL is distinct 
      from NLPHL and that it is closely related to the mixed cellularity CHL (MCHL) in 
      respect of BSAP, BOB.1, and Oct2 expression. It therefore occupies an 
      intermediate position between MCHL and NLPHL. Based on MUM1 staining, LRCHL 
      exhibits a more mature phenotype than NLPHL.
FAU - Steimle-Grauer, Susanne Annette
AU  - Steimle-Grauer SA
AD  - Senckenbergisches Institute of Pathology, Johann Wolfgang Goethe-University of 
      Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany. 
      Steimle-Grauer@em.uni-frankfurt.de
FAU - Tinguely, Marianne
AU  - Tinguely M
FAU - Seada, Laila
AU  - Seada L
FAU - Fellbaum, Christian
AU  - Fellbaum C
FAU - Hansmann, Martin-Leo
AU  - Hansmann ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030205
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Octamer Transcription Factor-2)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (PAX5 protein, human)
RN  - 0 (POU2AF1 protein, human)
RN  - 0 (POU2F2 protein, human)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (interferon regulatory factor-4)
SB  - IM
MH  - B-Lymphocytes/chemistry
MH  - *DNA-Binding Proteins/analysis
MH  - Hodgkin Disease/*metabolism/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Interferon Regulatory Factors
MH  - Lymph Nodes/chemistry/pathology
MH  - Octamer Transcription Factor-2
MH  - PAX5 Transcription Factor
MH  - Trans-Activators/analysis
MH  - *Transcription Factors/*analysis
EDAT- 2003/03/21 04:00
MHDA- 2003/05/13 05:00
CRDT- 2003/03/21 04:00
PHST- 2002/07/05 00:00 [received]
PHST- 2002/09/18 00:00 [accepted]
PHST- 2003/03/21 04:00 [pubmed]
PHST- 2003/05/13 05:00 [medline]
PHST- 2003/03/21 04:00 [entrez]
AID - 10.1007/s00428-002-0735-5 [doi]
PST - ppublish
SO  - Virchows Arch. 2003 Mar;442(3):284-93. doi: 10.1007/s00428-002-0735-5. Epub 2003 
      Feb 5.