PMID- 12648278
OWN - NLM
STAT- MEDLINE
DCOM- 20031112
LR  - 20191106
IS  - 0960-7420 (Print)
IS  - 0960-7420 (Linking)
VI  - 30
IP  - 2
DP  - 2003 Apr
TI  - HLA-DPB1*0401 is associated with dominant protection against type 1 diabetes in 
      the general Saudi population and in subjects with a high-risk DR/DQ haplotype.
PG  - 115-9
AB  - The human leukocyte antigen (HLA) class II DQB1*0201/0202-DRB1*04 genotype has 
      been identified as predisposing to type 1 diabetes [insulin-dependent diabetes 
      mellitus (IDDM)] in the Saudi Arabian population (P = 0.0002; odds ratio = 0.67; 
      95% confidence interval = 0.009-0.381). In this study, we searched for a factor 
      at the DPB1 locus by analysing DPB1 polymorphism using sequence-based typing in 
      86 Saudi IDDM patients and control subjects, all carrying the HLA-DRB1*04/DQB1*02 
      haplotype or the known susceptibility allele DQB1*0201/0202. Significant 
      protection was conferred by DPB1*0401, which was observed in 17 of 50 control 
      subjects (55%) and 2 of 36 IDDM patients (5%) with the DQB1*0201/0202 allele (P = 
      0.0012; odds ratio = 8.75; confidence interval = 1.72-59.70). Our data showing a 
      high frequency of the DPB1*0401 allele even in the presence of the predisposing 
      DQB1*02 allele in healthy subjects may indicate a protective effect of this 
      combination of HLA alleles against type 1 diabetes. This finding supports the 
      hypothesis that protective HLA class II genes can override the risk conferred by 
      HLA-DQ susceptibility alleles. Further studies using larger cohorts of control 
      subjects and patients should be undertaken to confirm this observation.
FAU - Al-Hussein, K A
AU  - Al-Hussein KA
AD  - Biological and Medical Research Department, King Faisal Specialist Hospital and 
      Research Center, Riyadh, Saudi Arabia. khussein@kfshrc.edu.sa
FAU - Rama, N R
AU  - Rama NR
FAU - Ahmad, M
AU  - Ahmad M
FAU - Rozemuller, E
AU  - Rozemuller E
FAU - Tilanus, M G
AU  - Tilanus MG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Immunogenet
JT  - European journal of immunogenetics : official journal of the British Society for 
      Histocompatibility and Immunogenetics
JID - 9106962
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - *Genes, Dominant
MH  - *Genetic Predisposition to Disease
MH  - HLA-DP Antigens/*genetics/metabolism
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Saudi Arabia
EDAT- 2003/03/22 04:00
MHDA- 2003/11/13 05:00
CRDT- 2003/03/22 04:00
PHST- 2003/03/22 04:00 [pubmed]
PHST- 2003/11/13 05:00 [medline]
PHST- 2003/03/22 04:00 [entrez]
AID - 369 [pii]
AID - 10.1046/j.1365-2370.2003.00369.x [doi]
PST - ppublish
SO  - Eur J Immunogenet. 2003 Apr;30(2):115-9. doi: 10.1046/j.1365-2370.2003.00369.x.