PMID- 12651072
OWN - NLM
STAT- MEDLINE
DCOM- 20040112
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 4
DP  - 2003 Apr
TI  - Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy 
      controls.
PG  - 458-61
AB  - The leukocyte immunoglobulinlike receptor (LILRA3; ILT6) gene is localized on 
      human chromosome 19 in the region 19q13.4, in the leukocyte receptor complex that 
      encodes leukocyte receptors LILR (ILT/LIR), killer cell immunoglobulinlike 
      receptors (KIR), LAIR, Fc IgA receptor, and others. The biologic role of the 
      LILRA3 molecule and the nature of its ligand are not known. Comparison of LILRA3 
      gene sequence with those of other LILRs suggests LILRA3 is a soluble molecule. If 
      LILRA3 binds human leukocyte antigen (HLA) class I molecules like other LILRs 
      whose ligands are known, then it might block recognition of HLA by these 
      receptors, influencing immune response and susceptibility to HLA class I 
      associated disease. A deletion of LILRA3 gene was found in a minority of British 
      population. We typed 108 healthy individuals from the Low Silesia region and 103 
      patients diagnosed with psoriasis vulgaris (a disease associated with HLA class I 
      antigen, HLA-Cw6) for LILRA3 to examine whether LILRA3 deletion was distributed 
      differently in patients affected with the disease. No differences in frequencies 
      of the LILRA3 deletion were found between controls and patients or between 
      HLA-Cw6(+) and HLA-Cw6(-) controls or patients, suggesting that LILRA3 has no 
      role in psoriasis.
CI  - Copyright American Society for Histocompatibility and Immunogenetics, 2003
FAU - Wisniewski, Andrzej
AU  - Wisniewski A
AD  - Laboratory of Immunogenetics, Department of Clinical Immunology, Ludwik Hirszfeld 
      Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 
      Wroclaw, Poland.
FAU - Luszczek, Wioleta
AU  - Luszczek W
FAU - Manczak, Maria
AU  - Manczak M
FAU - Jasek, Monika
AU  - Jasek M
FAU - Kubicka, Wioletta
AU  - Kubicka W
FAU - Cislo, Maria
AU  - Cislo M
FAU - Kusnierczyk, Piotr
AU  - Kusnierczyk P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-C*06 antigen)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - *Gene Deletion
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-C Antigens/genetics
MH  - Humans
MH  - Psoriasis/*genetics
MH  - Receptors, Immunologic/*genetics
EDAT- 2003/03/26 04:00
MHDA- 2004/01/13 05:00
CRDT- 2003/03/26 04:00
PHST- 2003/03/26 04:00 [pubmed]
PHST- 2004/01/13 05:00 [medline]
PHST- 2003/03/26 04:00 [entrez]
AID - S0198885903000259 [pii]
AID - 10.1016/s0198-8859(03)00025-9 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Apr;64(4):458-61. doi: 10.1016/s0198-8859(03)00025-9.