PMID- 12652153
OWN - NLM
STAT- MEDLINE
DCOM- 20030909
LR  - 20191106
IS  - 0929-5305 (Print)
IS  - 0929-5305 (Linking)
VI  - 14
IP  - 1
DP  - 2002 Aug
TI  - Association of changes in D-dimer and other coagulation markers with changes in 
      Marder score after treatment of acute venous thrombosis.
PG  - 73-8
AB  - AIM: Coagulation markers are sensitive tools to assess ongoing thrombus 
      formation. An association between changes in these markers and changes in 
      venographic Marder scores in patients with acute deep vein-thrombosis treated 
      with low-molecular-weight (LMWH) or unfractionated heparin (UFH) has not been 
      reported. METHODS: We investigated differences in coagulation parameters before 
      and at the end of a twelve days the treatment of patients with an improvement 
      versus no improvement of the venographic findings at the end of the treatment 
      with LMWH (n = 48) and UFH (n = 41). RESULTS: Patients with lower values in the 
      Marder score had lower D-dimer levels at day 12 compared to entry treated with 
      UFH and LMWH (p < 0.001). Not improved Marder scores paralleled unchanged D-dimer 
      levels at end of both treatments. Higher values of factor-Xa inhibition and 
      Heptest assay (p < 0.001) were measured at the end of treatment in LMWH- in 
      contrast to UFH-patients. Thrombin inhibition was lower and unchanged at day 12 
      in patients treated with LMWH and UFH, respectively. Thrombin generation 
      inhibition and release of tissue-factor pathway inhibitor remained unchanged in 
      both groups. CONCLUSION: An improved Marder score is associated with a decrease 
      of D-dimer during UFH and LMWH treatment of deep vein-thrombosis.
FAU - Harenberg, Job
AU  - Harenberg J
AD  - Forth Department of Medicine, University Hospital, Faculty of Clinical Medicine 
      Mannheim of the Ruprecht-Karls, University of Heidelberg, Mannheim, Germany. 
      j-harenberg@t-online.de
FAU - Merx, Kirsten
AU  - Merx K
FAU - Hoffmann, Ursula
AU  - Hoffmann U
FAU - Tolle, Alexander R
AU  - Tolle AR
FAU - Huisman, Menno V
AU  - Huisman MV
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Netherlands
TA  - J Thromb Thrombolysis
JT  - Journal of thrombosis and thrombolysis
JID - 9502018
RN  - 0 (Anticoagulants)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Coagulation Factors)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (fibrin fragment D)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Anticoagulants/*blood/therapeutic use
MH  - Biomarkers/blood
MH  - Blood Coagulation Factors/metabolism
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/*metabolism
MH  - Heparin, Low-Molecular-Weight/blood/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Statistics, Nonparametric
MH  - Venous Thrombosis/*blood/drug therapy
EDAT- 2003/03/26 04:00
MHDA- 2003/09/10 05:00
CRDT- 2003/03/26 04:00
PHST- 2003/03/26 04:00 [pubmed]
PHST- 2003/09/10 05:00 [medline]
PHST- 2003/03/26 04:00 [entrez]
AID - 5112415 [pii]
AID - 10.1023/a:1022022523146 [doi]
PST - ppublish
SO  - J Thromb Thrombolysis. 2002 Aug;14(1):73-8. doi: 10.1023/a:1022022523146.